ERF - ETS2 repressor factor Gene

中文名称：ETS2 抑制因子

种属: Homo sapiens

同用名: PE2; CRS4; PE-2; CHYTS

基因 ID: 2077 | 基因类型: protein coding

关于 ERF

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,247,569-42,255,128 (from NCBI)

This gene has 7 transcripts (splice variants), 249 orthologues, 28 paralogues and is associated with 6 phenotypes. Ubiquitous expression in kidney (RPKM 13.9), fat (RPKM 12.9) and 25 other tissues.

功能概要

ETS2 是一种转录因子和原癌基因，参与发育、细胞凋亡和端粒酶的调节。该基因编码的蛋白质与 ETS2 启动子结合，是 ETS2 转录的强阻遏物。已发现该基因编码两种不同亚型的几种转录变体。[RefSeq 提供，2015 年 8 月]

ETS2 is a transcription factor and protooncogene involved in development, Apoptosis, and the regulation of Telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

ERF 基因产物(4)

mRNA	Protein	Name
NM_001301035.2	NP_001287964.1	ETS domain-containing transcription factor ERF isoform 2
NM_001308402.2	NP_001295331.1	ETS domain-containing transcription factor ERF isoform 2
NM_001312656.2	NP_001299585.1	ETS domain-containing transcription factor ERF isoform 2
NM_006494.4	NP_006485.2	ETS domain-containing transcription factor ERF isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	7588608	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	23332764	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7588608	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ERF 蛋白结构

Ets

0
100
200
300
400
500
548 a.a.

蛋白主名

其他名称

ETS domain-containing transcription factor ERF

ERF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ERF	P50548	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
种属内	ERF	P50548	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
种属内	ERF	P50548	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
种属内	ERF	P50548	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	ERF	P50548	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	ERF	P50548	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	ERF	P50548	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
种属内	ERF	P50548	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
种属内	ERF	P50548	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
种属内	ERF	P50548	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
种属内	ERF	P50548	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
种属内	ERF	P50548	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Chitayat Syndrome

CHYTS

Bronchomalacia

Craniosynostosis 4

CRS4	Craniosynostosis, Type 4

Lambdoid Synostosis

Craniosynostosis, Lambdoidal

Synostotic Posterior Plagiocephaly

Non-Syndromic Sagittal Craniosynostosis

Isolated Sagittal Craniosynostosis	Isolated Scaphocephaly
Non-Syndromic Sagittal Suture Synostosis

Craniosynostosis 1

CRS	Congenital Rubella Syndrome
Craniostenosis	Congenital Rubella
CRS1	Craniosynostosis, Type 1
Rubella Congenital	Fetal Rubella Syndrome
Mother-To-Child Transmission Of Rubella Syndrome	Rubella, Congenital
Craniosynostosis	Gregg Syndrome

Crouzon Syndrome

Crouzon Craniofacial Dysostosis	Craniofacial Dysostosis
Cfd1	Craniofacial Dysostosis Type 1
Crouzon Disease	Crouzon'S Disease
Craniofacial Dysostosis, Type I	Craniofacial Dysarthrosis
Craniofacial Dysostosis Syndrome	CS
Craniofacial Dysostosis Type I	Vogt Cephalosyndactyly

Urethral False Passage

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Eastern Equine Encephalitis

Eee	Neuroinvasive Eastern Equine Encephalitis Virus Infection
Eastern Equine Encephalomyelitis	Encephalomyelitis, Eastern Equine
Triple E	Eastern Equine Encephalitis Virus Infection
Neuroinvasive Eastern Equine Encephalitis Virus Disease	Eee - [Eastern Equine Encephalitis]

Western Equine Encephalitis

Western Equine Encephalomyelitis	Wee
Encephalomyelitis, Western Equine	Western Equine Encephalitis Virus Infection
Wee - [Western Equine Encephalitis]	Western Equine Encephalitis Virus

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Bubonic Plague

Black Death	Plague, Bubonic
Plague, Septicemic	Pestis Bubonica

Septicemic Plague

Plague, Septicemic

Pfeiffer Syndrome

Infectious Mononucleosis	Acs5
Craniofacial-Skeletal-Dermatologic Dysplasia	Acs V
Noack Syndrome	Gammaherpesviral Mononucleosis
Acrocephalosyndactyly Type 5	Pfeiffer Syndrome Type 3
Acrocephalosyndactyly, Type V	Glandular Fever
Pfeiffer Type Acrocephalosyndactyly	Pfeiffer Syndrome Type 2
Acrocephalosyndactylia Type V	Filatov'S Disease
Monocytic Angina	Mononucleosis
Pfeiffer'S Disease	Acsv
Acrocephalosyndactyly, Type 5	Craniofacial-Skeletal-Dermatologic Syndrome
Pfeiffer Syndrome Type 1	Classic Pfeiffer Syndrome
PS	Pfeiffer Syndrome Variant
Dysplasia, Craniofacial-Skeletal-Dermatologic	Pfeiffer
Kissing Disease	Infectious Adenitis
Pfeiffer Disease

Pneumonic Plague

Primary Pneumonic Plague	Secondary Pneumonic Plague
Plague	Plague, Pneumonic
Plague Pneumonia	Plague Of Lung
Pulmonary Plague	Pneumonia Due To Yersinia Pestis

Nasal Cavity Lymphoma

Lymphoma Of Nasal Cavity

Lymphoma Of The Nasal Cavity

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Epstein-Barr Virus Hepatitis

Gaucher Disease, Type Ii

GD2	Gd Ii
Gaucher Disease, Acute Neuronopathic Type	Gaucher Disease Type 2
Gaucher Disease Type Ii	Gaucher'S Disease Type Ii
Infantile Cerebral Gaucher Disease	Acute Neuronopathic Gaucher Disease
Gd 2	Gaucher Disease, Infantile Cerebral
Gaucher Disease 2	Type 2 Gaucher Disease
Gaucher Disease, Type 2

Ross River Fever

Ross River Virus Disease

Ross River Virus Infection

Papillary Transitional Carcinoma

Papillary Transitional Cell Carcinoma

Brachydactyly

Plague

Yersiniosis	Yersinia Infections
Infection By Yersinia Pestis	Pasteurella Pestis Infection
Pestilential Fever	Yersinia Pestis Infection

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-150090	SRI-41315	Activator	99.68%	否
HY-163938	PROTAC erf3a Degrader-1		99.44%	否
HY-120743	Triplin		/	否
HY-153176	PAT-IN-1	Inhibitor	/	否
HY-153177	PAT-IN-2	Inhibitor	/	否
HY-163938A	PROTAC erf3a Degrader-2		/	否
HY-163960	NH2-Ph-NH-cyclohexane-NH-Boc		/	否
HY-163961A	Thalidomide-NH-cyclohexane-NH-Ph-NH2		/	否
HY-RS04488	ERF Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS04554	ETF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16710	Erf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20729	Etf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23145	Erf Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ERF	RGD	RGD:1311991
Bos taurus	ERF	VGNC	VGNC:28576
Macaca mulatta	ERF	VGNC	VGNC:108146
Canis familiaris	ERF	VGNC	VGNC:40447
Felis catus	ERF	VGNC	VGNC:61936
Mus musculus	ERF	MGD	MGI:109637
Macaca fascicularis	ERF	NCBI	NCBI:102115865
Canis lupus familiaris	ERF	NCBI
Susscrofa domestica	ERF	NCBI
Leporidae	ERF	NCBI
Others	ERF	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ERF - ETS2 repressor factor Gene

关于 ERF

功能概要

ERF 基因产物(4)

ERF 蛋白结构

ERF 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

ERF - ETS2 repressor factor Gene

关于 ERF

功能概要

ERF 基因产物(4)

ERF 蛋白结构

ERF 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z