Mlkl - mixed lineage kinase domain-like Gene

种属: Mus musculus

同用名: 9130019I15Rik

关于 Mlkl

功能概要

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced Necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in Necroptosis pathway. Knockout of this gene in mice showed that it is essential for Necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]