2. MAPK/ERK Pathway Apoptosis
  3. Mixed Lineage Kinase RIP kinase
  4. RIPK3-IN-3

RIPK3-IN-3 (compound 20) 是 RIP 激酶 (RIP kinase) RIPK3 的选择性抑制剂 (IC50=10 nM)。RIPK3 介导 Mixed Lineage Kinase (MLKL) 磷酸化并引起坏死性凋亡，RIPK3-IN-3 则抑制 p-MLKL 寡聚化从而抑制坏死性凋亡。RIPK3-IN-3 还下调 CXCL5 分泌，抑制 AsPC-1 细胞迁移和侵袭。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

RIPK3-IN-3 Chemical Structure

RIPK3-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

RIPK3-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1].

IC50 & Target

IC50: 10 nM (RIPK3)[1]
体外研究
(In Vitro)

RIPK3-IN-3 相关抗体:

Western Blot Analysis [1]

Cell Line: HT-29 cell
Concentration: 10, 25, 50 μM
Incubation Time: 2 h
Result: Inhibited phosphorylation of RIPK3 and MLKL in a concentration dependent manner.

Cell Viability Assay [1]

Cell Line: U937 cells, HT-29cell
Concentration: 20,50 μM
Incubation Time: 2 h
Result: Decreased PI-positive cells to Hoechst-positive cells ratio.
Rescued the cell from the TCZ-induced cell necroptosis.

Cell Migration Assay [1]

Cell Line: AsPC-1 cell
Concentration: 20,50 μM
Incubation Time: 24 h
Result: Suppressed migration capability of AsPC-1 pancreatic cancer cells in a dose dependent manner.

Cell Invasion Assay[1]

Cell Line: AsPC-1 cell
Concentration: 20,50 μM
Incubation Time: 2 h
Result: Suppressed invasion capability of AsPC-1 pancreatic cancer cells in a dose dependent manner.
体内研究
(In Vivo)
Animal Model: TNF-induced SIRS model (C57BL/6 female mice)[1]
Dosage: 10 or 25 mg/kg, single dose, TNFα (7 μg/mouse, iv)
Administration: Intraperitoneal injection (i.p.)
Result: Protects mice against lethal shock which is induced by TNFα and relieved the TNFα-induced temperature loss in a dose-dependent manner.
Decreases TNFα-induced IL-6 production in the mouse serum.
分子量

305.36

Formula

C16H11N5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RIPK3-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK3-IN-3Mixed Lineage KinaseRIP kinaseMLKsReceptor-interacting protein kinasesRIPKprogrammed necrotic cell deathTNFα-induced systemic inflammatory response syndromeHT-29Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
RIPK3-IN-3
目录号：
HY-149393
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z