2. Gene
  3. Cdkn1b - cyclin-dependent kinase inhibitor 1B Gene

Cdkn1b - cyclin-dependent kinase inhibitor 1B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: p27; Kip1; CDKN4; Cdki1b; P27KIP1

基因 ID: 83571 | 基因类型: protein coding

关于 Cdkn1b

功能概要

Enables HSP70 protein binding activity and chaperone binding activity. Involved in several processes, including regulation of cyclin-dependent protein serine/threonine kinase activity; response to estradiol; and response to glucose. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study cataract; endocrine organ benign neoplasm (multiple); infertility; multiple endocrine neoplasia; and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn1b 基因产物(1)

mRNA Protein Name
NM_031762.3 NP_113950.2 cyclin-dependent kinase inhibitor 1B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Hsp70 protein binding IPI
IPI: 通过物理相互作用推断
10198213 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9675118 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
10952244 RGD
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
10198213 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
28854428 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
23612739 RGD
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
22584582 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
28854428 RGD
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
22223646 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
17006629 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
16824045 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
16730872 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
18496635 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
15698433 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
15799773 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18490856 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
18496635 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18413661 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
10198213 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclin-dependent kinase inhibitor 1B

Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

cyclin-dependent kinase inhibitor p27

cyclin-dependent kinase inhibitor p27/Kip1

Cdkn1b 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Cdkn1b O08769 e1a_ade05 Human adenovirus C P03255
Pull Down
9675118
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02412 CDKN1B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19053 Cdkn1b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25543 Cdkn1b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdkn1b NCBI NCBI:1027
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