2. NF-κB Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Neuronal Signaling
  3. NF-κB MMP Calcium Channel
  4. GIP (22-51) human

GIP (22-51) human  (Synonyms: Glucose-dependent Insulinotropic Peptide (22-51) (human))

目录号: HY-P10972
产品使用指南 技术支持

GIP (22-51) human (Glucose-dependent Insulinotropic Peptide (22-51) human) 是一种有效的促动脉粥样硬化肽激素，由 30 个氨基酸组成。GIP (22-51) human 能激活 NF-κB 信号通路和促进 MMP-8 表达，以及诱导促炎和促动脉粥样硬化蛋白表达。GIP (22-51) human 也能增加 THP-1 诱导的巨噬细胞内游离 Ca2+ 水平。GIP (22-51) human 可用于脉粥样硬化的研究。

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GIP (22-51) human Chemical Structure

GIP (22-51) human Chemical Structure

CAS No. : 957470-49-4

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GIP (22-51) human 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GIP (22-51) human (Glucose-dependent Insulinotropic Peptide (22-51) human) is a potent proatherosclerotic peptide hormone consisting of 30 amino acids. GIP (22-51) human can activate the NF-κB signaling pathway, promote the expression of MMP-8, and induce the expression of proinflammatory and proatherosclerotic proteins. GIP (22-51) human can also increase the level of intracellular free Ca2+ in THP-1-induced macrophages. GIP (22-51) human can be used in the research of atherosclerosis[1].

IC50 & Target[1]

MMP-8

 

分子量

3181.56

Formula

C140H226N44O41
CAS 号
Sequence

Glu-Lys-Lys-Glu-Gly-His-Phe-Ser-Ala-Leu-Pro-Ser-Leu-Pro-Val-Gly-Ser-His-Ala-Lys-Val-Ser-Ser-Pro-Gln-Pro-Arg-Gly-Pro-Arg
Sequence Shortening

EKKEGHFSALPSLPVGSHAKVSSPQPRGPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GIP (22-51) human 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GIP (22-51) human957470-49-4Glucose-dependent Insulinotropic Peptide (22-51) (human)NF-κBMMPCalcium ChannelNuclear factor-κBNuclear factor-kappaBMatrix metalloproteinasesCa2+ channelsCa channelsHP1 cellsHAoECsHAoSMCsApo-/- miceInhibitorinhibitorinhibit

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