1. 诱导疾病模型产品 Immunology/Inflammation Autophagy Anti-infection
  2. 免疫与炎症疾病模型 皮肤疾病模型 Toll-like Receptor (TLR) Autophagy SARS-CoV HSV
  3. 银屑病模型
  4. Imiquimod maleate

Imiquimod maleate  (Synonyms: 马来酸咪喹莫特; R 837 maleate)

目录号: HY-B0180B 纯度: 99.25%
COA 产品使用指南

Imiquimod maleate (R 837 maleate) 是一种 toll 样受体7 (TLR7) 激动剂,作为一种免疫反应修饰剂。Imiquimod maleate 在体内表现出抗病毒和抗肿瘤作用。Imiquimod maleate 可用于外生殖器、肛周疣、癌症和 COVID-19 的研究。

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Imiquimod maleate Chemical Structure

Imiquimod maleate Chemical Structure

CAS No. : 896106-16-4

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3.  试用装只面向终端客户

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500 mg ¥1500
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Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 30 篇科研文献

WB

    Imiquimod maleate purchased from MCE. Usage Cited in: Nat Commun. 2016 May 25;7:11724.  [Abstract]

    Freshly prepared splenic B cells are left unstimulated (lanes 1 and 4), or stimulated by 10 μg/mL αIgM for 6 or 24 h (lanes 2 and 3), or by 1 μg/mL IMQ for 6, 24, 48 and 72 h (lanes 5-8), or by αIgM and IMQ for 24 or 48 h (lanes 9+10), respectively.

    查看 Toll-like Receptor (TLR) 亚型特异性产品:

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Imiquimod maleate (R 837 maleate), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

    IC50 & Target[1][3]

    TLR7

     

    HSV-1

     

    体内研究
    (In Vivo)

    In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    分子量

    356.38

    Formula

    C18H20N4O4

    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    马来酸咪喹莫特

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 25 mg/mL (70.15 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.8060 mL 14.0300 mL 28.0599 mL
    5 mM 0.5612 mL 2.8060 mL 5.6120 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.8060 mL 14.0300 mL 28.0599 mL 70.1498 mL
    5 mM 0.5612 mL 2.8060 mL 5.6120 mL 14.0300 mL
    10 mM 0.2806 mL 1.4030 mL 2.8060 mL 7.0150 mL
    15 mM 0.1871 mL 0.9353 mL 1.8707 mL 4.6767 mL
    20 mM 0.1403 mL 0.7015 mL 1.4030 mL 3.5075 mL
    25 mM 0.1122 mL 0.5612 mL 1.1224 mL 2.8060 mL
    30 mM 0.0935 mL 0.4677 mL 0.9353 mL 2.3383 mL
    40 mM 0.0701 mL 0.3507 mL 0.7015 mL 1.7537 mL
    50 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.4030 mL
    60 mM 0.0468 mL 0.2338 mL 0.4677 mL 1.1692 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Imiquimod maleate
    目录号:
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