2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. mGluR Histamine Receptor
  4. Oxomemazine hydrochloride

Oxomemazine hydrochloride 是一种基于吩噻嗪的组胺 H1 受体 (histamine H1-receptor) 阻滞剂，具有明显的抗毒蕈碱活性。Oxomemazine 是毒菌碱 M1 受体的选择性拮抗剂，在高 (histamine H1-receptor=84 nM, M1受体) 和低 (histamine H1-receptor=1.65 μM, M2受体) 亲和力位点上显示了 20 倍的差异。Oxomemazine 是一种用于咳嗽研究相关研究的一种抗组胺和抗胆碱能试剂。

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Oxomemazine hydrochloride Chemical Structure

Oxomemazine hydrochloride Chemical Structure

CAS No. : 4784-40-1

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Oxomemazine hydrochloride 相关抗体

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生物活性

Oxomemazine hydrochloride is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine hydrochloride is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki= 84 nM, M1 receptor) and low (Ki= 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine hydrochloride an antihistamine and anticholinergic agent used for the study of cough treatment[2].

IC50 & Target

mGluR 1

84 nM (Ki)

mGluR2

1.65 μM (Ki)

分子量

366.91

Formula

C18H23ClN2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Oxomemazine hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Oxomemazine4784-40-1mGluRHistamine ReceptorMetabotropic glutamate receptorshistamine H1-receptormuscarinic M1 receptorcoughInhibitorinhibitorinhibit

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