2. PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK Apoptosis
  3. PI3K VEGFR Apoptosis
  4. PI3K/VEGFR2-IN-1

PI3K/VEGFR2-IN-1 是一种有效的双重 PI3K/VEGFR2 抑制剂，抑制 PI3K 和 VEGFR2 的 IC50 值分别为 2.21 和 68 μM。PI3K/VEGFR2-IN-1 诱导细胞凋亡 (apoptosis)。PI3K/VEGFR2-IN-1 可用于癌症的研究。

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PI3K/VEGFR2-IN-1 Chemical Structure

PI3K/VEGFR2-IN-1 Chemical Structure

CAS No. : 2851067-08-6

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PI3K/VEGFR2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/VEGFR2-IN-1 is a potent dual PI3K/VEGFR2 inhibitor with IC50 values of 2.21 and 68 μM for PI3K and VEGFR2, respectively. PI3K/VEGFR2-IN-1 induces apoptosis. PI3K/VEGFR2-IN-1 can be used in research of cancer[1].

IC50 & Target[1]

PI3K

2.21 μM (IC50)

VEGFR2

68 μM (IC50)

体外研究
(In Vitro)

PI3K/VEGFR2-IN-1 (compound 8; 1.56-100 µM; 24 h; HePG2, MCF-7, Hela, and PC3 cells) inhibits cell proliferative in a dose-dependent manner[1].
PI3K/VEGFR2-IN-1 (10 mg/mL; 24 h; MCF-7 and Hela cells) arrests cell cycle at G1/S phase and induces apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/VEGFR2-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: HePG2, MCF-7, Hela, and PC3 cells
Concentration: 1.56-100 µM
Incubation Time: 24 hours
Result: Had antitumor activity with IC50 values of 7.94, 9.73 , 11.58, and 17.49 µM for Hela, HePG2, MCF-7 and PC3 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 10 mg/mL
Incubation Time: 24 hours
Result: Arrested cell cycle in G1/S phase at 24 h by 51.23%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 and Hela cells
Concentration: 10 mg/mL
Incubation Time: 24 hours
Result: Enhanced late apoptotic induction with 14.11% at Hela cells.
分子量

343.83

Formula

C17H14ClN3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/VEGFR2-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/VEGFR2-IN-12851067-08-6PI3KVEGFRApoptosisPhosphoinositide 3-kinaseVascular endothelial growth factor receptoranticancercell proliferativeHelaMCF-7cell cycleG1/S phaseInhibitorinhibitorinhibit

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