Poly-L-lysine hydrobromide (MW 30000-70000) 

Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material^{[1][2][3][4][5][6][7][8]}.

Poly-L-lysine hydrobromide (MW 30000-70000) (0.1-25 µg/mL, 24 h) 对人类癌细胞表现出抗增殖活性，对 K562、A549、U937 和 B16F10 细胞的 IC₅₀ 值分别为 3.36 µM、8.23 µM、3.53 µM 和 6.04 µM^[2]。
Poly-L-lysine hydrobromide (MW 30000-70000) (0.5-40 µg/mL, 48 h) 在 MCF-7 细胞中表现出抗增殖活性 (IC₅₀ 值为 4.22 µg/mL)^[3]。
Poly-L-lysine hydrobromide (MW 30000-70000) (0.5-30.0 μg/mL，24-72 h) 可降低体外 HUVEC 和 DAL 细胞的细胞增殖，并改变 DAL 细胞的细胞形态^[4]。
Poly-L-lysine hydrobromide (MW 30000-70000) (0-200 μg/mL) 可刺激用 [³H] 花生四烯酸生物合成标记的 3T3 瑞士小鼠成纤维细胞培养物中花生四烯酸的释放^[5]。
Poly-L-lysine hydrobromide (MW 30000-70000) (在工作 pH 下，等电点 ∼10.5)/肝素多层涂层可防止血液蛋白吸附^[6]。
Poly-L-lysine hydrobromide (MW 30000-70000) (1.0-40.0 μg/mL，48 h) 抑制 MDA-MB-231 和 B16F10 癌细胞的增殖^[7]。
Poly-L-lysine hydrobromide (MW 30000-70000) (10-120 μg/mL，2-4 h) 剂量依赖性地降低 HeLa 细胞的活力^[8]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Poly-L-lysine hydrobromide (MW 30000-70000) (20-40 mg/kg，腹腔注射，14 天) 可抑制小鼠艾氏腹水癌 (EAC)，导致 EAC 细胞凋亡^[2]。
Poly-L-lysine hydrobromide (MW 30000-70000) (20-40 mg/kg，腹腔注射，21 天) 可抑制瑞士雌性白化小鼠的肉瘤-180 实体肿瘤^[2]。
Poly-L-lysine hydrobromide (MW 30000-70000) (20-40 mg/kg，腹腔注射，肿瘤接种后 10 天开始，持续 21 天) 可抑制 DAL 实体肿瘤的生长小鼠^[4]。
Poly-L-lysine hydrobromide (MW 30000-70000) (20-40 mg/kg，腹腔注射，肿瘤接种后 10 天开始，持续 21 天) 可在 MDA-MB-231 和 B16F10 诱导小鼠模型的 2D 和 3D 肿瘤微环境中诱导细胞凋亡^[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

30000-70000

C₈H₁₉BrN₂O

25988-63-0

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Archishman Ghosh, et al. Three archetypical classes of macromolecular regulators of protein liquid-liquid phase separation. Proc Natl Acad Sci U S A. 2019;116(39):19474-19483.  [Content Brief]

  [2]. Debnath S, et al. Poly-L-Lysine Inhibits Tumor Angiogenesis and Induces Apoptosis in Ehrlich Ascites Carcinoma and in Sarcoma S-180 Tumor. Asian Pac J Cancer Prev. 2017 Aug 27;18(8):2255-2268.  [Content Brief]

  [3]. Mukherjee A, et al. DNA interactive property of poly-L-lysine induces apoptosis in MCF-7 cells through DNA interaction. J Biochem Mol Toxicol. 2023 Aug;37(8):e23378.  [Content Brief]

  [4]. Debnath S, et al. Induction of apoptosis, anti-proliferation, tumor-angiogenic suppression and down-regulation of Dalton's Ascitic Lymphoma (DAL) induced tumorigenesis by poly-l-lysine: A mechanistic study. Biomed Pharmacother. 2018 Jun;102:1064-1076.  [Content Brief]

  [5]. Shier WT, et al. Polycations as prostaglandin synthesis inducers. Stimulation of arachidonic acid release and prostaglandin synthesis in cultured fibroblasts by poly(L-lysine) and other synthetic polycations. Biochim Biophys Acta. 1984 Apr 18;793(2):238-50.  [Content Brief]

  [6]. Barrantes A, et al. Poly-l-lysine/heparin multilayer coatings prevent blood protein adsorption. J Colloid Interface Sci. 2017 Jan 1;485:288-295.  [Content Brief]

  [7]. Debnath S, et al. Poly-l-Lysine inhibits VEGF and c-Myc mediated tumor-angiogenesis and induces apoptosis in 2D and 3D tumor microenvironment of both MDA-MB-231 and B16F10 induced mice model. Int J Biol Macromol. 2021 Jul 31;183:528-548.  [Content Brief]

  [8]. Lin CW, et al. Protective role of autophagy in branched polyethylenimine (25K)- and poly(L-lysine) (30-70K)-induced cell death. Eur J Pharm Sci. 2012 Dec 18;47(5):865-74.  [Content Brief]