2. Neuronal Signaling Autophagy Apoptosis
  3. Monoamine Oxidase Autophagy Apoptosis
  4. Rasagiline mesylate

Rasagiline mesylate  (Synonyms: 甲磺酸雷沙吉兰; (R)-AGN1135 mesylate; TVP1012 mesylate)

目录号: HY-14605 纯度: 99.77%
COA 产品使用指南

摩尔计算器

Rasagiline (R-AGN1135) mesylate 是一种高效的不可逆的选择性线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的 IC50 分别为 4.43 nM 和 412 nM。Rasagiline (mesylate) 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Rasagiline mesylate Chemical Structure

Rasagiline mesylate Chemical Structure

CAS No. : 161735-79-1

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥275
In-stock
5 mg ￥250
In-stock
10 mg ￥350
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50 mg ￥500
In-stock
100 mg ￥800
In-stock
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500 mg   询价  

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Customer Review

Other Forms of Rasagiline mesylate:

Rasagiline mesylate 相关抗体

Top Publications Citing Use of Products

    Rasagiline mesylate purchased from MCE. Usage Cited in: Oncotarget. 2018 Jan 30;9(15):12137-12153.  [Abstract]

    Retinal protection of Rasagiline combined with Idebenone against retinal ischemia-reperfusion (RIR) injury. Western blot analysis for the expression level of brain-derived neurotrophic factor (BDNF) in the whole IR-injured retinas.

    查看 Monoamine Oxidase 亚型特异性产品:

    查看所有亚型
    MAO-A MAO-B

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively[1]. Rasagiline (mesylate) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

    IC50 & Target[1]

    rMAO-B

    4.43 nM (IC50)

    rMAO-A

    412 nM (IC50)

    体外研究
    (In Vitro)

    Rasagiline (0.25 nM; 96 hours) significantly increases the proliferation rates of SH-SY5Y and 1242-MG upon Dexamethasone (10 µM) treatment[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Rasagiline mesylate 相关抗体:

    Cell Viability Assay[2]

    Cell Line: Neuroblastoma SH-SY5Y, and glioblastoma 1242-MG
    Concentration: 0.25 nM
    Incubation Time: 96 hours
    Result: Caused ~60% increase in the cell proliferation rate for SH-SY5Y cells treated with Dexamethasone.
    Caused ~35% increase in cell proliferation rate for 1242-MG cells treated with Dexamethasone.
    体内研究
    (In Vivo)

    Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Motor behavioural tests show improvements in motor deficits associated with 2.5 mg/kg Rasagiline therapy[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: (PLP)-α-synuclein transgenic mice over 6 months of age[3]
    Dosage: Low-(0.8 mg/kg b.w.) and high dose (2.5 mg/kg b. w.)
    Administration: Administered subcutaneously every 24 h for a total period of 4 weeks (from day 1 till day 28 of the experiment).
    Result: Low dose treatment did not show protective efficacy in striatum with number of neurons similar to placebo treated MSA mice. High dose was associated with about 15% rescue of DARPP-32 immunoreactive striatal neurons.
    Low dose treatment had no effect on nigral neuronal loss, but high dose completely protected nigral neurons with numbers comparable to healthy controls.
    Clinical Trial
    分子量

    267.34

    Formula

    C13H17NO3S
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    雷沙吉兰甲磺酸；甲磺酸雷沙吉兰
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : 25 mg/mL (93.51 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.7406 mL 18.7028 mL 37.4056 mL
    5 mM 0.7481 mL 3.7406 mL 7.4811 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: 100 mg/mL (374.06 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.77%

    COA (173 KB) LCMS (89 KB)

    产品使用指南 (1538 KB)
    参考文献

    Rasagiline mesylate 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.7406 mL 18.7028 mL 37.4056 mL 93.5139 mL
    5 mM 0.7481 mL 3.7406 mL 7.4811 mL 18.7028 mL
    10 mM 0.3741 mL 1.8703 mL 3.7406 mL 9.3514 mL
    15 mM 0.2494 mL 1.2469 mL 2.4937 mL 6.2343 mL
    20 mM 0.1870 mL 0.9351 mL 1.8703 mL 4.6757 mL
    25 mM 0.1496 mL 0.7481 mL 1.4962 mL 3.7406 mL
    30 mM 0.1247 mL 0.6234 mL 1.2469 mL 3.1171 mL
    40 mM 0.0935 mL 0.4676 mL 0.9351 mL 2.3378 mL
    50 mM 0.0748 mL 0.3741 mL 0.7481 mL 1.8703 mL
    60 mM 0.0623 mL 0.3117 mL 0.6234 mL 1.5586 mL
    80 mM 0.0468 mL 0.2338 mL 0.4676 mL 1.1689 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Rasagiline161735-79-1(R)-AGN1135TVP1012雷沙吉兰甲磺酸甲磺酸雷沙吉兰TVP 1012TVP-1012Monoamine OxidaseAutophagyApoptosisMAOInhibitorinhibitorinhibit

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    目录号：
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