2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB 258741 hydrochloride

SB 258741 hydrochloride 是一种特异性的 5-HT7 受体拮抗剂，可用于精神分裂症的研究。

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SB 258741 hydrochloride Chemical Structure

SB 258741 hydrochloride Chemical Structure

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SB 258741 hydrochloride 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB 258741 hydrochloride is a specific 5-HT7 receptor antagonist and can be used for the research of schizophrenia[1].

IC50 & Target

5-HT7 Receptor

 

体外研究
(In Vitro)

SB-258741 behaves as a partial inverse agonist, the antagonist potency (apparent pKB) is 8.47[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SB 258741 hydrochloride 相关抗体:
体内研究
(In Vivo)

SB 258741 (0-9.1 mg/kg; s.c.; once or daily for 3 days) shows antipsychotic effects in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats, 250 –300 g in the phencyclidine (PCP)-disrupted prepulse inhibition (PPI) and PCP-disrupted social interaction (SIT) paradigm, 200 – 250 g in the catalepsy, motility, and D-amphetamine hyperactivity paradigms[1]
Dosage: 0.56, 2.3, 4.6 and 9.1 mg/kg
Administration: Subcutaneous injection, once or daily for 3 days (social interaction test)
Result: Reversed hyperactivity induced by D-amphet-amine over 0.56 mg/kg, and reduced motility at 4.6 and 9.1 mg/kg.
Did not reverse D-Amphetamine-disrupted PPI, but enhanced PCP-disrupted PPI.
Reduced PCP (2 mg/kg)-induced hyperactivity.
分子量

386.98

Formula

C19H31ClN2O2S
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB 258741 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB 258741SB258741SB-2587415-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorschizophreniaprepulse inhibitionInhibitorinhibitorinhibit

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产品名称：
SB 258741 hydrochloride
目录号：
HY-136678A
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