2. Others PI3K/Akt/mTOR Autophagy Apoptosis
  3. Reference Standards PI3K Akt mTOR Autophagy Apoptosis
  4. Veratramine (Standard)

Veratramine (Standard)  (Synonyms: 黎芦碱 (Standard); NSC17821 (Standard); NSC23880 (Standard))

目录号: HY-N0837R 纯度: ≥98%
产品使用指南 技术支持

Veratramine (NSC17821; NSC23880) (Standard) 是 Veratramine (HY-N0837) 的分析标准品。本产品用于研究及分析应用。Veratramine (NSC17821; NSC23880) 是一种口服有效的 PI3K/Akt/mTOR 信号通路抑制剂及 SIGMAR1 调节剂。Veratramine 诱导肿瘤细胞自噬性凋亡 (autophagy)，阻滞细胞周期于 G0/G1 期，并抑制上皮-间质转化 (EMT) 相关蛋白减少肿瘤迁移。Veratramine 通过抑制 SIGMAR1 与 NMDAR 结合及 NMDAR Ser896 位点磷酸化，减轻神经病变模型中脊髓和坐骨神经病理损伤。Veratramine 具有抗肿瘤增殖、诱导凋亡 (apoptosis、抑制炎症及神经保护活性，可用于肝癌、骨肉瘤等癌症及糖尿病周围神经病变的研究。

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Veratramine (Standard) Chemical Structure

Veratramine (Standard) Chemical Structure

CAS No. : 60-70-8

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规格 价格 是否有货 数量
5 mg ￥780
4 - 5 周
10 mg ￥1250
4 - 5 周
25 mg ￥2250
4 - 5 周
50 mg ￥3600
4 - 5 周
100 mg ￥5760
4 - 5 周
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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生物活性

Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy.

分子量

409.60

Formula

C27H39NO2
CAS 号
中文名称

黎芦碱 (Standard)；黎芦胺 (Standard)；藜芦铵 (Standard)
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Veratramine (Standard) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Veratramine (Standard)60-70-8NSC17821 (Standard)NSC23880 (Standard)黎芦碱 (Standard)黎芦胺 (Standard)藜芦铵 (Standard)Reference StandardsPI3KAktmTORAutophagyApoptosisPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinInhibitorinhibitorinhibit

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