2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Ziprasidone mesylate

Ziprasidone mesylate  (Synonyms: 齐拉西酮; CP-88059 mesylate)

目录号: HY-14542C
产品使用指南

摩尔计算器

Ziprasidone (CP-88059) mesylate 是一种具有口服活性的 5-HT 和多巴胺 (dopamine) 受体拮抗剂。Ziprasidone mesylate 对大鼠 D2 (Ki=4.8 nM)、5-HT2A (Ki=0.42 nM) 和 5-HT1A (Ki=3.4 nM) 有亲和作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ziprasidone mesylate Chemical Structure

Ziprasidone mesylate Chemical Structure

CAS No. : 185021-64-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Ziprasidone mesylate 的其他形式现货产品:

Customer Review

Other Forms of Ziprasidone mesylate:

Ziprasidone mesylate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ziprasidone (CP-88059) mesylate is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone mesylate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1].

IC50 & Target

Rat 5-HT2 Receptor

0.42 nM (Ki)

Rat 5-HT1A Receptor

3.4 nM (Ki)

Rat D2 Receptor

4.8 nM (Ki)

体外研究
(In Vitro)

Ziprasidone mesylate (0-500 nM, 150 seconds) blocks wild-type hERG current[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ziprasidone mesylate 相关抗体:

Cell Viability Assay[2]

Cell Line: HEK-293 cells
Concentration: 0-500 nM
Incubation Time: 150 seconds
Result: Blocked wild-type hERG current in a voltage- and concentration-dependent manner (IC50 = 120 nm).
体内研究
(In Vivo)

Ziprasidone mesylate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3]
Dosage: 20 mg/kg
Administration: Oral gavage; 20 mg/kg; once daily; 7 weeks
Result: Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
Clinical Trial
分子量

509.04

Formula

C22H25ClN4O4S2
CAS 号
中文名称

齐拉西酮甲磺酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ziprasidone mesylate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziprasidone185021-64-1CP-88059齐拉西酮甲磺酸盐CP88059CP 880595-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine Receptorantipsychotic agent5-HT receptorserotonindopamine receptorHEK-293Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Ziprasidone mesylate
目录号：
HY-14542C
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z