2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. 17(R)-Resolvin D1

17(R)-Resolvin D1  (Synonyms: 17(R)-RvD1; AT-RvD1)

目录号: HY-125527A
产品使用指南

摩尔计算器

17R-Resolvin D1 (17R-RvD1; AT-RvD1) 是阿司匹林触发的 Resolvin D1 的差向异构体，在小鼠和人 PMNS 细胞中都表现出抗炎活性。17R-Resolvin D1 特异性抑制 TRPV3，IC50 为 398 nM，并表现出外周镇痛作用。

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17(R)-Resolvin D1 Chemical Structure

17(R)-Resolvin D1 Chemical Structure

CAS No. : 528583-91-7

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Other Forms of 17(R)-Resolvin D1:

17(R)-Resolvin D1 相关抗体

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy[2].

IC50 & Target

TRPV3

398 nM (IC50)

体外研究
(In Vitro)

17R-Resolvin D1 (0-1000 nM) 剂量依赖性地减少 fMLP 诱导的人多形核白细胞 (PMN) 的跨内皮迁移，发挥抗急性炎症的作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

17(R)-Resolvin D1 相关抗体:

Cell Migration Assay [1]

Cell Line: PMNs
Concentration: 0-1000 nM
Incubation Time: 30 min
Result: Reduced fMLP-induced human PMNs transendothelial migration in a dose-dependent manner, reduced 65% PMNs transmigration at the concentration of 1 μM.
体内研究
(In Vivo)

17R-Resolvin D1 (0.05-50 μg/kg，静脉注射) 减少 FVB 小鼠体内的 PMN 细胞浸润，在 100 ng/kg 剂量时达到最大抑制浓度，一直比例为 35%[1]。
17R-Resolvin D1 (30 µM in 20 µL，皮内注射) TRPV3 特异性地减轻 ICR 小鼠体内由 CFA 诱导的急性疼痛[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine peritonitis bearing FVB mice[1]
Dosage: 0.05-50 μg/kg
Administration: i.v., single dosage
Result: Reduced total leukocytic infiltration, the maximal decrease in total leukocytes with a 100 ng dose.
Animal Model: CFA-inflamed ICR mice[2]
Dosage: 30 µM in 20 µL
Administration: i.d.
Result: Reduced the heat threshold in animals with a CFA-inflamed hind paw.
分子量

376.49

Formula

C22H32O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

17(R)-Resolvin D1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

17(R)-Resolvin D1528583-91-717(R)-RvD1 AT-RvD1TRP ChannelTransient receptor potential channelshuman polymorphonuclear leukocyteperitonitisFVB miceInhibitorinhibitorinhibit

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