2'-Deoxyuridine-¹³C,¹⁵N₂  (Synonyms: 2'-脱氧尿苷-¹³C,¹⁵N₂)

2'-Deoxyuridine-¹³C,¹⁵N₂ is the ¹³C and ¹⁵N labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

231.18

C₈¹³CH₁₂¹⁵N₂O₅

369656-76-8

固体

White to off-white

2'-脱氧尿苷-¹³C,¹⁵N₂； 2-脱氧尿苷-¹³C,¹⁵N₂

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.  [Content Brief]