2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. (24S,25)-Epoxycholesterol

24S,25-Epoxycholesterol 是肝脏 X 受体 (LXR) 的激动剂。24S,25-Epoxycholesterol 具有调节胆固醇流出、抑制胃癌和胶质母细胞瘤肿瘤生长的特性并诱导 BMMC 细胞凋亡 (apoptosis)。

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(24S,25)-Epoxycholesterol Chemical Structure

(24S,25)-Epoxycholesterol Chemical Structure

CAS No. : 77058-74-3

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(24S,25)-Epoxycholesterol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

24S,25-Epoxycholesterol is an agonist for Liver X Receptor (LXR). 24S,25-Epoxycholesterol exhibits properties in regulating the cholesterol efflux[1], inhibiting tumor growth against gastric cancer and glioblastoma[2][3] and inducing apoptosis in BMMC cells[5].

体外研究
(In Vitro)

24S,25-Epoxycholesterol (1-10 μM) 上调 LXR 相关基因 ABCA1、ABCG1 和 APOE，促进胆固醇流出，从而防止泡沫细胞形成，并通过消除细胞胆固醇来阻止小鼠和人类神经胶质瘤干细胞的增殖[1][3]。
24S,25-Epoxycholesterol 抑制 HGC27 的增殖和迁移，敲除 LXRβ 可增强这种增殖和迁移[2]。
24S,25-Epoxycholesterol (40 μM) 抑制 HMG-CoA 还原酶并激活 LXR，从而抑制甲羟戊酸 (mevalonate) 依赖性类异戊二烯 (isoprenoid) 的生成并增强 ATP 结合盒转运蛋白 G1 表达，诱导骨髓源性小鼠肥大细胞 (BMMC) 凋亡[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(24S,25)-Epoxycholesterol 相关抗体:

Cell Proliferation Assay[2]

Cell Line: HGC27
Concentration: 1 μM
Incubation Time: 18 h
Result: Inhibited proliferation of HGC27

Cell Migration Assay [2]

Cell Line: HGC27
Concentration: 1 μM
Incubation Time: 18 h
Result: Reduced HGC27 migration.
体内研究
(In Vivo)

24S,25-Epoxycholesterol (5 mM，脑室注射) 可增强 CYP46A1 过表达小鼠中脑的中脑多巴胺神经元 (mDA) 神经发生、限制神经变性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GGPP induced mDA neurogenesis defect in CYP46A1 overexpressing CD-1 mice[4]
Dosage: 5 mM
Administration: icv, 1 μL, single dosage
Result: Increased levels of mDA neurons, blocked the GGPP induced decrease of double EdU and TH cells.
分子量

400.64

Formula

C27H44O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(24S,25)-Epoxycholesterol 相关分类

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Keywords:

(24S,25)-Epoxycholesterol77058-74-3LXRLiver X receptorgastric cancerParkinson's diseaserheumatoid arthritismultiple sclerosistype I allergiesBMMCHGC27Inhibitorinhibitorinhibit

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