1. 天然产物
  2. 疾病研究领域 植物 苯丙素类
  3. 茄科 癌症 炎症/免疫 香豆素
  4. 白英
  5. 4'',5''-Dehydroisopsoralidin

4'',5''-Dehydroisopsoralidin 是一种 β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂(IC50: 6.3 μM)。4'',5''-Dehydroisopsoralidin 具有抗炎和抗氧化作用。4'',5''-Dehydroisopsoralidin 可用于炎症和癌症的研究。

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4'',5''-Dehydroisopsoralidin Chemical Structure

4'',5''-Dehydroisopsoralidin Chemical Structure

CAS No. : 65639-51-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC50: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners[1][2].

IC50 & Target

β-glucuronidase[1]

体外研究
(In Vitro)

4'',5''-Dehydroisopsoralidin (compound 5, 15 min) inhibits the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) of rats, with an IC50 value of 6.3 μM[1].
4'',5''-Dehydroisopsoralidin (compound 9, 24 h) shows weak cytotoxicity (IC50: >50 μM) to H4IIE, HCT116, C6 cells[2].
4'',5''-Dehydroisopsoralidin (25 μM, 1h) causes significant radical scavenging in H4IIE rat hepatoma cells (TEAC assay)[2].
4'',5''-Dehydroisopsoralidin (compound 5, 15 μM, 60 h) increases lifespan in P. corylifolia (MEP assay)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

334.32

Formula

C20H14O5

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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产品名称:
4'',5''-Dehydroisopsoralidin
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HY-N9975
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