2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. 48740 RP

48740 RP  (Synonyms: RP-55778)

目录号: HY-100153
产品使用指南

摩尔计算器

48740 RP (RP-55778) 是一种血小板激活因子 (PAF) 拮抗剂。

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48740 RP Chemical Structure

48740 RP Chemical Structure

CAS No. : 93363-11-2

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规格 价格 是否有货
1 mg ￥7200
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48740 RP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist.

IC50 & Target

PAF[1]
体内研究
(In Vivo)

48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

245.30

Formula

C12H11N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Guinea pigs of both sexes weighing 300 to 500 g are used for the determination of free lung cell responses and histopathologic examination. Male hamsters, weighing 100 g, are used for capillary permeability determinations. Guinea pigs are pretreated with an intraperitoneal injection of 48740 RP at 20 mg/kg in saline 1 h before exposure to lipopolysaccharide (LPS) and immediately thereafter. Groups of hamsters (n=6) are treated immediately before aerosol exposure, immediately after, and 3 h afterwards[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

48740 RP 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

48740 RP93363-11-2RP-55778RP55778RP 55778Platelet-activating Factor Receptor (PAFR)Inhibitorinhibitorinhibit

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目录号：
HY-100153
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