1. Protein Tyrosine Kinase/RTK
  2. Trk Receptor

7,8-Dihydroxyflavone 

目录号: HY-W013372
产品使用指南

7,8-二羟基黄酮7,8-Dihydroxyflavone是有效和选择性的 TrkB 激动剂,其模拟脑源性神经营养因子 (BDNF) 的生理作用。 显示对各种神经疾病的治疗功效。

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7,8-Dihydroxyflavone Chemical Structure

7,8-Dihydroxyflavone Chemical Structure

CAS No. : 38183-03-8

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥880 In-stock
50 mg ¥800 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].

IC50 & Target

TrkB[1]

In Vitro

7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1].

In Vivo

7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1].

Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2].

References
Molecular Weight

254.24

Formula

C₁₅H₁₀O₄

CAS No.

38183-03-8

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
7,8-Dihydroxyflavone
目录号:
HY-W013372
需求量:

7,8-Dihydroxyflavone

Cat. No.: HY-W013372