2. Cytoskeleton
  3. Integrin
  4. Arg-Gly-Asp-Ser

Arg-Gly-Asp-Ser  (Synonyms: RGDS peptide; Fibronectin tetrapeptide)

目录号: HY-12290 纯度: 99.93%
COA 产品使用指南

摩尔计算器

Arg-Gly-Asp-Ser 是整联蛋白结合序列，抑制整联蛋白受体 (integrin receptor) 功能。Arg-Gly-Asp-Ser 直接并特异性地结合 pro-caspase-8，pro-caspase-9 和 pro-caspase-3，但不与 pro-caspase-1 结合。

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Custom Peptide Synthesis

Arg-Gly-Asp-Ser Chemical Structure

Arg-Gly-Asp-Ser Chemical Structure

CAS No. : 91037-65-9

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥335
In-stock
5 mg ￥305
In-stock
10 mg ￥550
In-stock
50 mg ￥1750
In-stock
100 mg ￥3150
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Arg-Gly-Asp-Ser:

Arg-Gly-Asp-Ser 相关抗体

Top Publications Citing Use of Products

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

体外研究
(In Vitro)

Arg-Gly-Asp-Ser 修饰的表面导致 αvβ3 整合素的上调。附着在 Arg-Gly-Asp-Ser 处理的膜上完全消除了星形孢菌素、Ca2+·Pi 离子对和硝普钠诱导的细胞凋亡。当磷脂酰肌醇 3-激酶途径的活性受到抑制时，Arg-Gly-Asp-Ser 依赖性细胞凋亡抗性被消除[1]。
Arg-Gly-Asp-Ser 与存活蛋白以及 procaspase-3、-8 和-9 相互作用。Arg-Gly-Asp-Ser -peptide 与生存素的结合被发现是特异性的，具有高亲和力 (Kd 27.5 μM) 并且位于生存素的 C 末端。Arg-Gly-Asp-Ser -survivin 相互作用似乎发挥了关键作用，因为 Arg-Gly-Asp-Ser 在具有特定 siRNA 的生存素剥夺细胞中失去了抗有丝分裂作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Arg-Gly-Asp-Ser 相关抗体:
体内研究
(In Vivo)

Arg-Gly-Asp-Ser (2.5 或 5 mg/kg，LPS 前 1 小时) 显著抑制 LPS 后 4 小时 BAL 液中 LPS 诱导的 MMP-9 活性。Arg-Gly-Asp-Ser (1、2.5 或 5 mg/kg，腹腔注射) 在 LPS 前 1 小时给药，抑制 LPS 诱导的 BAL 液中 TNF-α 和 MIP-2 水平在 LPS 后 4 小时增加[2]。
Arg-Gly-Asp-Ser 肽可显著降低肿瘤坏死因子 (TNF)-α 和巨噬细胞炎症蛋白 (MIP)-2 的产生，并降低髓过氧化物酶 (MPO) 和 NF-κB 活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

433.42

Formula

C15H27N7O8
CAS 号
性状

固体

颜色

White to off-white

Sequence

Arg-Gly-Asp-Ser
Sequence Shortening

RGDS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (115.36 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : ≥ 25 mg/mL (57.68 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3072 mL 11.5362 mL 23.0723 mL
5 mM 0.4614 mL 2.3072 mL 4.6145 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.93%

COA (191 KB) LCMS (87 KB) 元素分析报告 (208 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

Cell death is measured using the MTT analysis. This assay is based on the ability of mitochondrial dehydrogenases to oxidize thiazolyl blue (MTT), a tetrazolium salt (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenylterazolium bromide), to an insoluble blue formazan product. The cells are incubated with the MTT reagent (120 μg/mL) at 37°C for 2 h. After the supernatant is removed, 400 μL of 0.04mol/LHCl in isopropanol is added to each well, and the optical density of the solution is read at 590 nm in an enzyme-linked immunosorbent assay plate reader. As the generation of the blue product is proportional to the dehydrogenase activity, a decrease in the absorbance at 590 nm provides a direct measurement of the number of viable cells. To determine the contribution of the PI3K pathway to inhibition of apoptosis, some cell populations are pretreated with 50 μM LY294002, a PI3K inhibitor. Following this pretreatment, cell death is determined as described above.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Mice pharyngeal aspiration is performed as described. Animals are anesthetized with a mixture of ketamine and xylazine (45 mg/kg and 8 mg/kg, i.p., respectively). Test solution (30 μL) containing LPS (1.5 mg/kg) is placed posterior in the throat and aspirated into the lungs. Control mice are administrated sterile saline (0.9% NaCl). Animals are administered with Arg-Gly-Asp-Ser or RGES peptide (1, 2.5 or 5 mg/kg, i.p.) once one hour before LPS treatment and sacrificed 4 h post-LPS. Animals are also administered Arg-Gly-Asp-Ser or RGES peptide (5 mg/kg, i.p.) once at different time points (1 h before or 2 h after LPS treatment) and sacrificed 24 h post-LPS. In addition, animals are administered with αvβ3-blocking mAbs, anti-αv, or anti-β3 (5 mg/kg, i.p.) once 1 h before and sacrificed 4 h post-LPS. Animals administered with these mAbs 2 h after LPS treatment are sacrificed 24 h post-LPS

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Arg-Gly-Asp-Ser 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.3072 mL 11.5362 mL 23.0723 mL 57.6808 mL
5 mM 0.4614 mL 2.3072 mL 4.6145 mL 11.5362 mL
10 mM 0.2307 mL 1.1536 mL 2.3072 mL 5.7681 mL
15 mM 0.1538 mL 0.7691 mL 1.5382 mL 3.8454 mL
20 mM 0.1154 mL 0.5768 mL 1.1536 mL 2.8840 mL
25 mM 0.0923 mL 0.4614 mL 0.9229 mL 2.3072 mL
30 mM 0.0769 mL 0.3845 mL 0.7691 mL 1.9227 mL
40 mM 0.0577 mL 0.2884 mL 0.5768 mL 1.4420 mL
50 mM 0.0461 mL 0.2307 mL 0.4614 mL 1.1536 mL
DMSO 60 mM 0.0385 mL 0.1923 mL 0.3845 mL 0.9613 mL
80 mM 0.0288 mL 0.1442 mL 0.2884 mL 0.7210 mL
100 mM 0.0231 mL 0.1154 mL 0.2307 mL 0.5768 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arg-Gly-Asp-Ser91037-65-9RGDS peptide Fibronectin tetrapeptideIntegrinInhibitorinhibitorinhibit

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