2. GPCR/G Protein
  3. Endothelin Receptor
  4. Atrial Natriuretic Peptide (ANP) (1-28), rat

Atrial Natriuretic Peptide (ANP) (1-28), rat  (Synonyms: Atrial natriuretic factor (1-28) (rat))

目录号: HY-P1236 纯度: 96.37%
COA 产品使用指南

摩尔计算器

Atrial Natriuretic Peptide (ANP) (1-28), rat 是心房利钠肽 (ANP) 在大鼠中的主要循环形式，强效抑制血管紧张素 II (Ang II)-刺激的内皮素-1 (endothelin-1) 分泌。

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Custom Peptide Synthesis

Atrial Natriuretic Peptide (ANP) (1-28), rat Chemical Structure

Atrial Natriuretic Peptide (ANP) (1-28), rat Chemical Structure

CAS No. : 88898-17-3

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规格 价格 是否有货 数量
500 μg ￥1800
In-stock
1 mg ￥2800
In-stock
5 mg ￥9800
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Atrial Natriuretic Peptide (ANP) (1-28), rat:

Atrial Natriuretic Peptide (ANP) (1-28), rat 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atrial Natriuretic Peptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

IC50 & Target

Endothelin-1[1]
体外研究
(In Vitro)

大鼠 ANP (1-28) 和大鼠 BNP-45 分别是大鼠 ANP 和 BNP 的主要循环形式，它们以浓度依赖性方式有效抑制 Ang II 刺激的内皮素-1 分泌。在抑制免疫反应性 (ir)-endothelin-1 分泌和增加细胞循环 GMP 方面，大鼠 ANP (5-25) 不如大鼠 ANP (1-28) 有效。Rat ANP (1-28) 在 0.01 和 1 μM 之间以浓度依赖性方式抑制 ir-endothelin-1 的分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Atrial Natriuretic Peptide (ANP) (1-28), rat 相关抗体:
分子量

3062.41

Formula

C128H205N45O39S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)
Sequence Shortening

SLRRSSCFGGRIDRIGAQSGLGCNSFRY (Disulfide bridge: Cys7-Cys23)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Atrial Natriuretic Peptide (ANP) (1-28), rat 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atrial Natriuretic Peptide (ANP) (1-28), rat88898-17-3Atrial natriuretic factor (1-28) (rat)Endothelin ReceptorInhibitorinhibitorinhibit

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产品名称：
Atrial Natriuretic Peptide (ANP) (1-28), rat
目录号：
HY-P1236
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