2. Neuronal Signaling
  3. Amyloid-β
  4. BF-168

BF-168 是 PET 的候选探针，能够特异性识别神经和弥漫性斑块，其对 Aβ1-42 的 Ki 值为 6.4 nM。

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BF-168 Chemical Structure

BF-168 Chemical Structure

CAS No. : 634911-47-0

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Free Sample (0.1 - 0.2 mg)   Apply now  
1 mg ￥1727
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5 mg ￥3800
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10 mg ￥6000
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Customer Review

BF-168 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.

IC50 & Target

Ki: 6.4 nM (Aβ1-42)[1].
体外研究
(In Vitro)

BF-168, a styrylbenzoxazole derivative, is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BF-168 相关抗体:
体内研究
(In Vivo)

Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice result in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t1/2=24.7 min) after intravenous administration in normal mice. Furthermore, autoradiograms of brain sections from APP23 transgenic mice at 180 min after intravenous injection of [18F]BF-168 shows selective labeling of brain amyloid deposits with little nonspecific binding[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

312.34

Formula

C18H17FN2O2
CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (160.08 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2016 mL 16.0082 mL 32.0164 mL
5 mM 0.6403 mL 3.2016 mL 6.4033 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

BF-168 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2016 mL 16.0082 mL 32.0164 mL 80.0410 mL
5 mM 0.6403 mL 3.2016 mL 6.4033 mL 16.0082 mL
10 mM 0.3202 mL 1.6008 mL 3.2016 mL 8.0041 mL
15 mM 0.2134 mL 1.0672 mL 2.1344 mL 5.3361 mL
20 mM 0.1601 mL 0.8004 mL 1.6008 mL 4.0020 mL
25 mM 0.1281 mL 0.6403 mL 1.2807 mL 3.2016 mL
30 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6680 mL
40 mM 0.0800 mL 0.4002 mL 0.8004 mL 2.0010 mL
50 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
60 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3340 mL
80 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0005 mL
100 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8004 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BF-168634911-47-0BF168BF 168Amyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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产品名称：
BF-168
目录号：
HY-112830
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