2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Doxefazepam

Doxefazepam  (Synonyms: SAS-643)

目录号: HY-101808 纯度: 99.99%
COA 产品使用指南

摩尔计算器

Doxefazepam 是一种苯二氮卓类 (benzodiazepine) 衍生物，具有抗焦虑，抗惊厥作用。

该产品由公安部研究所生产，销售、运输全流程受严格监管。MCE 的所有产品仅用作科学研究或药证申报，请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

Doxefazepam Chemical Structure

Doxefazepam Chemical Structure

CAS No. : 40762-15-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥2500
In-stock
10 mg ￥4000
In-stock
25 mg ￥7800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Doxefazepam 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Doxefazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsan and skeletal muscle relaxant properties.

IC50 & Target

Benzodiazepine[1]
体内研究
(In Vivo)

Groups of 50 male and 50 female Sprague-Dawley rats are given food containing sufficient Doxefazepam, a benzodiazepine derivative, to ensure intakes of 0, 3, 10, or 30 mg/kg/day. Rats are treated for 104 weeks and then euthanized. An extensive autopsy is performed on those animals that died intercurrently and on euthanized animals. The chronic administration of Doxefazepam does not influence the survival of the rats. A significant linear trend in the incidence of hepatocellular neoplasms, primarily benign, is observed in the female treated groups. This higher incidence is not associated to a higher occurrence of focal hyperplasia or other preneoplastic lesions in treated rats. The brain, a target organ for the pharmacological activity of Doxefazepam, is carefully examined to search for microscopic foci of proliferative cells. A total of 12 and 6 malignant gliomas are observed in male and female rats, respectively; only two are noticed at autopsy. These tumors are mainly of the oligodendroglioma type commonly found in aged rats[1]. Doxefazepam is investigated in a series of toxicological studies. Oral LD50 values are greater than 2000 mg/kg in mice, rats and dogs, while endoperitoneal LD50 values are 746 and 544 mg/kg in the mice and rats, respectively, and greater than 1000 mg/kg in the dogs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

348.76

Formula

C17H14ClFN2O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

度氟西泮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (716.83 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8673 mL 14.3365 mL 28.6730 mL
5 mM 0.5735 mL 2.8673 mL 5.7346 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Doxefazepam 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8673 mL 14.3365 mL 28.6730 mL 71.6825 mL
5 mM 0.5735 mL 2.8673 mL 5.7346 mL 14.3365 mL
10 mM 0.2867 mL 1.4337 mL 2.8673 mL 7.1683 mL
15 mM 0.1912 mL 0.9558 mL 1.9115 mL 4.7788 mL
20 mM 0.1434 mL 0.7168 mL 1.4337 mL 3.5841 mL
25 mM 0.1147 mL 0.5735 mL 1.1469 mL 2.8673 mL
30 mM 0.0956 mL 0.4779 mL 0.9558 mL 2.3894 mL
40 mM 0.0717 mL 0.3584 mL 0.7168 mL 1.7921 mL
50 mM 0.0573 mL 0.2867 mL 0.5735 mL 1.4337 mL
60 mM 0.0478 mL 0.2389 mL 0.4779 mL 1.1947 mL
80 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8960 mL
100 mM 0.0287 mL 0.1434 mL 0.2867 mL 0.7168 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxefazepam40762-15-0SAS-643度氟西泮SAS643SAS 643GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Doxefazepam
目录号：
HY-101808
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z