1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

ERK2 IN-1 

目录号: HY-112300
产品使用指南

ERK2 IN-1 是一种选择性 ERK2 抑制剂,IC50 为 7 nM。

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ERK2 IN-1 Chemical Structure

ERK2 IN-1 Chemical Structure

CAS No. : 1093061-47-2

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Description

ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM[1].

IC50 & Target[1]

ERK2

7 nM (IC50)

In Vitro

ERK1/2 IN-1 (Compound 28) maintains good ERK enzymatic activity (ERK IC50=7 nM) and cellular activity in BRAF/KRAS mutant wildtype cancer cell lines (HT-29/Caspase IC50=118/80 nM)[1].

References
Molecular Weight

647.76

Formula

C₃₆H₃₄FN₇O₂S

CAS No.

1093061-47-2

SMILES

FC1=CC=C(C2=NNC3=C2C=C(NC([C@@]4(SC)CN(CC(N5CCC(C6=CC=C(C7=NC=CC=N7)C=C6)=CC5)=O)CC4)=O)C=C3)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
ERK2 IN-1
目录号:
HY-112300
需求量:

ERK2 IN-1

Cat. No.: HY-112300