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F 16915 

目录号: HY-19886
产品使用指南

F 16915 是一个二十二碳六烯酸衍生物,可预防心力衰竭引起的心房纤颤。

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F 16915 Chemical Structure

F 16915 Chemical Structure

CAS No. : 92510-91-3

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥18490 In-stock
1 mg ¥12520 In-stock
5 mg ¥20030 In-stock
10 mg ¥32730 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation.

In Vivo

F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation. Time-dependent changes in blood concentrations of total docosahexaenoic acid (DHA) and nicotinyl alcohol are followed after a single oral administration of F 16915 (300 mg/kg) to male rats. Treatment with F 16915 has no significant effect on body weight: 27.7±2.9 kg and 28.1±1.0 kg before surgery versus 29.2±3.4 kg and 28.8±1.7 kg after in the 1 and 5 g/day groups, respectively. F 16915 administered at 5 g/day for 4 weeks significantly reduces the mean duration of Atrial fibrillation (AF) induced by burst pacing but has no significant effect at 1 g/day. The duration of AF is significantly reduced from 989±111 s in the placebo group to 79±59 s in the presence of F 16915 at 5 g/day. Treatment of 2 months with 100 mg/kg F 16915 also significantly reduces the infarct size[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3832 mL 11.9161 mL 23.8322 mL
5 mM 0.4766 mL 2.3832 mL 4.7664 mL
10 mM 0.2383 mL 1.1916 mL 2.3832 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Male Sprague-Dawley rats weighing 220 to 300 g are used in this study. The rats are anesthetized using isoflurane 3% on O2. Then, the animals are intubated and ventilated at 60 respirations/min (2.5 mL/respiration) while anesthesia is maintained. A left thoracotomy is performed, and a silk suture is placed around the left coronary artery ~1 mm from its origin. The treatment starts just after the surgery. A single administration of 100 mg/kg F 16915 or vehicle (olive oil) is daily administrated orally by force-feeding[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

419.60

Formula

C₂₈H₃₇NO₂

CAS No.

92510-91-3

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(OCC1=CC=CN=C1)=O

Storage

-20°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
F 16915
目录号:
HY-19886
需求量:

F 16915

Cat. No.: HY-19886