1. Apoptosis
  2. Ferroptosis
  3. Imidazole ketone erastin

Imidazole ketone erastin (Synonyms: IKE)

目录号: HY-114481
产品使用指南

Imidazole ketone erastin (IKE)是一种有效的,选择性的,代谢稳定的胱氨酸-谷氨酸逆转运蛋白,system Xc- 抑制剂和 ferroptosis 活化剂。

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Imidazole ketone erastin Chemical Structure

Imidazole ketone erastin Chemical Structure

CAS No. : 1801530-11-9

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥3603 In-stock
5 mg ¥2500 In-stock
10 mg ¥3500 In-stock
50 mg ¥11000 In-stock
100 mg ¥18000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Other Forms of Imidazole ketone erastin:

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Description

Imidazole ketone erastin (IKE) s a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis.

IC50 & Target

System Xc-, ferroptosis[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (190.80 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5264 mL 7.6320 mL 15.2639 mL
5 mM 0.3053 mL 1.5264 mL 3.0528 mL
10 mM 0.1526 mL 0.7632 mL 1.5264 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.17 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.17 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

655.14

Formula

C₃₅H₃₅ClN₆O₅

CAS No.

1801530-11-9

SMILES

O=C1N(C2=CC(C(CN3C=CN=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=CC=CC=C61

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Imidazole ketone erastin
目录号:
HY-114481
需求量:

Imidazole ketone erastin

Cat. No.: HY-114481