1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. JAK1-IN-4

JAK1-IN-4 

目录号: HY-116505
产品使用指南

JAK1-IN-4 是一种有效、选择性的 JAK1 抑制剂,对 JAK1,JAK2 和 JAK3 的 IC50 值分别为 85 nM,12.8 μM 和 >30 μM。在 NCI-H 1975 细胞中,JAK1-IN-4 抑制 STAT3 的磷酸化,IC50 值为 227 nM。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

JAK1-IN-4 Chemical Structure

JAK1-IN-4 Chemical Structure

CAS No. : 2091134-35-7

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products

View All JAK Isoform Specific Products:

  • 生物活性

  • 技术信息

  • 纯度 & 产品资料

  • 参考文献

Description

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].

IC50 & Target[1]

JAK1

85 nM (IC50)

JAK2

12.8 μM (IC50)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

521.59

Formula

C₂₆H₃₂FN₉O₂

CAS No.

2091134-35-7

SMILES

O=C(NC1=CC=CC2=C1NC=C2C3=C(C=NC(NC4=CN(N=C4OC)C)=N3)F)[C@H](N5CCN([C@@H](C5)C)C)C

Shipping

Room temperature in continental US; may vary elsewhere

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
JAK1-IN-4
目录号:
HY-116505
需求量:

JAK1-IN-4

Cat. No.: HY-116505