2. Others NF-κB
  3. Biochemical Assay Reagents NF-κB
  4. N,N-Dimethylacetamide

N,N-Dimethylacetamide  (Synonyms: 二甲基乙酰胺; DMAc)

目录号: HY-W042416 纯度: 99.96%
COA 产品使用指南

摩尔计算器

N,N-Dimethylacetamide (DMAc) 是一种具有血脑透过性的有机溶剂和 FDA 批准的药物辅料。N,N-Dimethylacetamide 通过抑制 NF-κB 信号通路发挥抗炎活性。N,N-Dimethylacetamide 可用于高脂肪饮食引起的体重增加和阿尔茨海默病的神经炎症的研究。

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N,N-Dimethylacetamide Chemical Structure

N,N-Dimethylacetamide Chemical Structure

CAS No. : 127-19-5

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100 mL ￥550
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Customer Review

Other Forms of N,N-Dimethylacetamide:

N,N-Dimethylacetamide 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease[1][2][3].

体外研究
(In Vitro)

N,N-Dimethylacetamide (10-1000 μM, 24 h) 在 RAW 264.7 细胞中抑制巨噬细胞的杀菌活性[1]。
N,N-Dimethylacetamide (0.1-10 mM, 2 h) 在小胶质细胞系 SIM-A9 和 HMC3 中可抑制 a β 诱导的炎症[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N,N-Dimethylacetamide 相关抗体:

Western Blot Analysis[2]

Cell Line: SIM-A9, HMC3
Concentration: 0.1, 1, 10 mM
Incubation Time: 2 h
Result: Diminished iNOS production.
Decreased Aβ42 in a concentration-dependent manner.
Reduced APP and p-APP protein levels at 1 and 10 mM.
Increased IκBα levels in SIM-A9 cells with both 1 mM and 10 mM and in HMC3 cells with 10 mM.
体内研究
(In Vivo)

N,N-Dimethylacetamide (0.2, 0.39, 0.78, 1.56, 3.1 mg/kg, 腹腔注射) 可预防内毒素诱导的 C57BL/6 胚胎日 (E) 15.5 小鼠的早产，并以剂量依赖的方式使其幼崽免于自然流产[1]。
N,N-Dimethylacetamide (2.1 g/kg/day, 腹腔注射) 可减弱 DSS 诱导的结肠炎的临床和组织学特征[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-Triggered PTB and Spontaneous Abortions mice[1]
Dosage: 0.2, 0.39, 0.78, 1.56, 3,1 mg/kg
Administration: i.p. Single dose
Result: Attenuated the excessive endotoxin-triggered proinflammatory response that leads to preterm delivery.
Animal Model: DSS-induced colitis in C57Bl/6 mice[3]
Dosage: 2.1 g/kg
Administration: i.p. once a day for four days
Result: Attenuated inflammation, crypt injury and ulceration.
分子量

87.12

Formula

C4H9NO
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

二甲基乙酰胺；N,N-二甲基乙酰胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 100 mg/mL (1147.84 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.96%

COA (191 KB) HNMR (112 KB) GC (195 KB)

产品使用指南 (1538 KB)
参考文献

N,N-Dimethylacetamide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 11.4784 mL 57.3921 mL 114.7842 mL 286.9605 mL
5 mM 2.2957 mL 11.4784 mL 22.9568 mL 57.3921 mL
10 mM 1.1478 mL 5.7392 mL 11.4784 mL 28.6961 mL
15 mM 0.7652 mL 3.8261 mL 7.6523 mL 19.1307 mL
20 mM 0.5739 mL 2.8696 mL 5.7392 mL 14.3480 mL
25 mM 0.4591 mL 2.2957 mL 4.5914 mL 11.4784 mL
30 mM 0.3826 mL 1.9131 mL 3.8261 mL 9.5654 mL
40 mM 0.2870 mL 1.4348 mL 2.8696 mL 7.1740 mL
50 mM 0.2296 mL 1.1478 mL 2.2957 mL 5.7392 mL
60 mM 0.1913 mL 0.9565 mL 1.9131 mL 4.7827 mL
80 mM 0.1435 mL 0.7174 mL 1.4348 mL 3.5870 mL
100 mM 0.1148 mL 0.5739 mL 1.1478 mL 2.8696 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N-Dimethylacetamide127-19-5DMAc二甲基乙酰胺N,N-二甲基乙酰胺Biochemical Assay ReagentsNF-κBNuclear factor-κBNuclear factor-kappaBDMAAnti-inflammatoryHigh fat dietADDSSSIM-A9HMC3RAW 264.7Inhibitorinhibitorinhibit

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