2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics
  3. NAMPT AMPK mTOR
  4. STF-118804

STF-118804是烟酰胺磷酸核糖基转移酶NAMPT高选择性抑制剂。STF-118804 可激活 AMPK 并抑制 mTOR 通路。STF-118804 对胰腺癌具有抗肿瘤活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

STF-118804 Chemical Structure

STF-118804 Chemical Structure

CAS No. : 894187-61-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥660
In-stock
5 mg ￥600
In-stock
10 mg ￥920
In-stock
25 mg ￥1900
In-stock
50 mg ￥3100
In-stock
100 mg ￥4600
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

STF-118804 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 AMPK 亚型特异性产品:

查看所有亚型
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates AMPK and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B-ALL EC50
0.061 μM
Compound: 1
Antiproliferative activity against mouse B-ALL BCR-ABL double knockout cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse B-ALL BCR-ABL double knockout cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
B-ALL EC50
0.072 μM
Compound: 1
Antiproliferative activity against mouse B-ALL cells expressing wild type BCR-ABL assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse B-ALL cells expressing wild type BCR-ABL assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
BJ EC50
2.4938 μM
Compound: 1
Antiproliferative activity against human BJ assessed as cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human BJ assessed as cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
K562 EC50
4.6 μM
Compound: 1
Antiproliferative activity against human K562 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human K562 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
KOPN-8 EC50
1.23 μM
Compound: 1
Antiproliferative activity against human KOPN8 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human KOPN8 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
MV4-11 EC50
3.8 μM
Compound: 1
Antiproliferative activity against human MV411 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MV411 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
NALM-6 EC50
0.026 μM
Compound: 1
Antiproliferative activity against human NALM6 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human NALM6 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
SUP-B15 EC50
1.1 μM
Compound: 1
Antiproliferative activity against human SUP-B15 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human SUP-B15 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
UoC-B1 EC50
> 54.98 μM
Compound: 1
Antiproliferative activity against human UOCB1 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human UOCB1 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 30611980]
体外研究
(In Vitro)

STF-118804 (6.25-25 nM，72 h) 抑制不同胰腺导管腺癌细胞 (PaTu8988t、Panc-1、Su86.86、Panc04.03) 的活力和生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STF-118804 相关抗体:

Cell Viability Assay[1]

Cell Line: PaTu8988t, Panc-1, Su86.86, Panc04.03
Concentration: 6.25, 12.5, 25 nM
Incubation Time: 72 h
Result: Showed more sensitivity to Panc-1 and PaTu8988t cells.
体内研究
(In Vivo)

STF-118804 (25 mg/kg，腹腔注射，3 周) 在 PDAC (Panc-1) 原位移植小鼠模型中表现出抗肿瘤活性[1]。
STF-118804 (50 mg/kg，皮下注射，20 天) 可提高高风险急性淋巴细胞白血病原位异种移植小鼠的生存率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (gender not specified, age 4 - 6 weeks) inoculated with Panc-1 cells expressing GFP-luciferase to establish an orthotopic pancreatic cancer model[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection (i.p.), 3 weeks
Result: Reduced tumor growth as demonstrated by decreased luminescence, tumor weight and size.
Had no significant toxicity.
分子量

461.54

Formula

C25H23N3O4S
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (54.17 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1666 mL 10.8332 mL 21.6665 mL
5 mM 0.4333 mL 2.1666 mL 4.3333 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.72%

COA (286 KB) HNMR (277 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

STF-118804 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1666 mL 10.8332 mL 21.6665 mL 54.1661 mL
5 mM 0.4333 mL 2.1666 mL 4.3333 mL 10.8332 mL
10 mM 0.2167 mL 1.0833 mL 2.1666 mL 5.4166 mL
15 mM 0.1444 mL 0.7222 mL 1.4444 mL 3.6111 mL
20 mM 0.1083 mL 0.5417 mL 1.0833 mL 2.7083 mL
25 mM 0.0867 mL 0.4333 mL 0.8667 mL 2.1666 mL
30 mM 0.0722 mL 0.3611 mL 0.7222 mL 1.8055 mL
40 mM 0.0542 mL 0.2708 mL 0.5417 mL 1.3542 mL
50 mM 0.0433 mL 0.2167 mL 0.4333 mL 1.0833 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STF-118804894187-61-2STF118804STF 118804NAMPTAMPKmTORNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorAMP-activated protein kinaseMammalian target of RapamycinInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
STF-118804
目录号：
HY-12808
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z