1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker

ADC Linker

Antibody-drug conjugates (ADCs) are a new class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer. ADCs are complex molecules composed of an antibody, a linker and a biological active cytotoxic. ADCs linkers are based on chemical motifs including disulfides, hydrazones or peptides (cleavable), or thioethers (noncleavable) and control the distribution and delivery of the cytotoxic agent to the target cell. Cleavable and noncleavable types of linkers have been proven to be safe in preclinical and clinical trials. A stable link between the antibody and cytotoxic (anti-cancer) agent is a crucial aspect of an ADC.

ADC Linker 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-20336
    Mc-Val-Cit-PABC-PNP
    Mc-Val-Cit-PABC-PNP是可用组织蛋白酶切割的ADC多肽连接桥。 FDA批准的药物brentuximab vedotin采用了该接头。
  • HY-78738
    MC-Val-Cit-PAB 99.56%
    MC-Val-Cit-PAB是可被组织蛋白酶切割的ADC连接桥,用于制备抗体-药物偶联物。 美国FDA批准的药物,如布伦替卡韦,血清素使用了该连接桥。
  • HY-41189
    Fmoc-Val-Cit-PAB-PNP
    Fmoc-Val-Cit-PAB-PNP是一种多肽前体药物连接子,是抗体偶联药物 (ADC) 的常用连接桥
  • HY-12362
    Val-cit-PAB-OH 99.35%
    Val-cit-PAB-OH是一种多肽前体药物连接子.
  • HY-21210
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- 是抗体偶联药物 (ADC) 的连接桥。
  • HY-78961
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester 99.96%
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS)是抗体偶联药物(ADC)中常用保护基团。
  • HY-19318
    Fmoc-Val-Cit-PAB
    Fmoc-Val-Cit-PAB是抗体偶联药物(ADC)的常用连接桥。
  • HY-20560
    (Ac)Phe-Lys(Alloc)-PABC-PNP
    (Ac)Phe-Lys(Alloc)-PABC-PNP是抗体偶联药物(ADC)的常用连接桥。