1. Metabolic Enzyme/Protease
  2. Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA. The malonyl-CoA produced by ACC serves two major physiologic functions. It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1). Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer.

Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Acetyl-CoA Carboxylase 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-16901
    ND-630 Inhibitor 98.72%
    ND-630是乙酰辅酶A羧化酶 (ACC) 抑制剂,抑制人类ACC1和ACC2的IC50值分别为2.1和6.1 nM。
  • HY-15259A
    CP-640186 hydrochloride Inhibitor 99.40%
    CP-640186盐酸盐是乙酰辅酶A羧化酶(ACCase)抑制剂,对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM,比CP-610431有着更好的代谢稳定性。
  • HY-101068
    TOFA Inhibitor >98.0%
    TOFA (RMI14514;MDL14514)是乙酰辅酶A羧化酶-α (ACCA )的变构抑制剂。
  • HY-17641
    Olumacostat glasaretil Inhibitor >98.0%
    Olumacostat glasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。
  • HY-101842
    ND-646 Inhibitor 98.39%
    ND-646 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,抑制重组 hACC1 和 hACC2,IC50 分别为 3.5 nM 和 4.1 nM。
  • HY-N0523
    Gallic acid Inhibitor 99.97%
    Gallic acid 是可以抑制 COX-2 和乙酰辅酶 A 羧化酶 (ACC) 的抗氧化剂。
  • HY-12942
    PF-05175157 Inhibitor 98.74%
    PF-05175157 是一种广谱乙酰辅酶 A 羧化酶 (ACC) 抑制剂,对 ACC1 (human),ACC2 (human), ACC1 (rat) 和 ACC2 (rat) 的 IC50 值分别为 27.0, 33.0, 23.5 和 50.4 nM。
  • HY-15259
    CP-640186 Inhibitor
    CP-640186是乙酰辅酶A羧化酶(ACCase)抑制剂,对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM,比CP-610431有更好的代谢稳定性。