1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

Aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast cancer stem cells (CSCs), in triple negative breast cancer (TNBC) tissues.

Mitochondrial aldehyde dehydrogenase (ALDH2) is a member of the 19-strong human aldehyde dehydrogenase family of NADP+-dependent enzymes.

ALDH2, a mitochondrial enzyme responsible for metabolizing the major lipid peroxidation product, protects against acute ischemia/reperfusion injury and chronic heart failure. Activation of ALDH2, the main enzyme that catalyzes 4-HNE metabolism, is sufficient to protect the heart against acute ischemia-reperfusion injury.

ALDH2 is a key detoxifying enzyme. ALDH2 is most commonly associated with its role in ethanol metabolism, catalyzing the oxidation of ethanol-derived acetaldehyde to acetate.

Aldehyde Dehydrogenase (ALDH) 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-18936
    Alda-1 Agonist 99.70%
    Alda-1 是有效的 ALDH2 激动剂,能够显著提高 ALDH2 的活性。
  • HY-B0240
    Disulfiram Inhibitor 98.13%
    Disulfiram 是特异性的乙醛脱氢酶1型抗体 (ALDH1) 抑制剂,可以通过对酒精产生急性敏感性来治疗慢性酗酒。
  • HY-18768
    NCT-501 Inhibitor 99.75%
    NCT-501是一种茶碱类的有效醛脱氢酶1A1 (ALDH1A1) 选择性抑制剂, 抑制hALDH1A1时IC50值为40 nM, 选择性超过其它ALDH同工酶和其它脱氢酶 (作用于hALDH1B1, hALDH3A1, 和hALDH2时, IC50值 >57 UM)。