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Androgen Receptor

Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS).

Androgen Receptor 相关产品 (46):

Cat. No. Product Name Effect Purity
  • HY-70002
    Enzalutamide Antagonist 99.71%
    Enzalutamide 是一种雄激素受体 (androgen-receptor) 拮抗剂,作用于 LNCaP 细胞,IC50 为 36 nM。
  • HY-16060
    ARN-509 Antagonist 99.23%
    ARN-509 是一种有效的竞争性的 雄激素受体 (AR) 拮抗剂,IC50 为 16 nM。
  • HY-14650
    DHEA Inhibitor >98.0%
    DHEA 是雄激素重要来源,是一种有效的抗细胞凋亡因子。
  • HY-14249
    Bicalutamide Agonist 99.61%
  • HY-15194
    ASC-J9 Inhibitor 98.06%
    ASC-J9 是一种抗肿瘤药,同过降解全长和剪接的 androgen 受体变体来抑制前列腺癌细胞的生长。
  • HY-B0626
    Testosterone undecanoate Agonist >98.0%
    Testosterone undecanoate是睾酮酯,用做男性节育。
  • HY-103184
    GT0918 Antagonist
    GT0918 是一种有效的雄激素受体 (AR) 的拮抗剂。
  • HY-103576
    LGD-3303 Modulator 98.27%
    LGD-3303 是一种选择性雄激素受体调节剂 (SARM)。
  • HY-B0022
    Flutamide Antagonist 99.01%
    Flutamide是抗雄激素化合物,能与其活性代谢物一起与雄激素受体相结合,Ki为55 nM,可作用于前列腺癌。
  • HY-B1269
    Testosterone propionate Agonist 99.90%
    Testosterone Propionate是一种有效的雄性激素, 治疗低睾酮症。
  • HY-16985
    ODM-201 Antagonist
    ODM-201是有效的雄激素受体(AR)拮抗剂, 在AR-HEK293细胞中的IC50值为26 nM。
  • HY-B0561
    Spironolactone Antagonist
  • HY-B1029
    Danazol Agonist 98.28%
    Danazol是合成类固醇Ethisterone的衍生物, 抑制促性腺激素产生, 且具有一定的弱雄激素作用。
  • HY-15758
    3,3'-Diindolylmethane Antagonist 98.74%
    3,3'-Diindolylmethane 是一种有效的雄激素受体 (AR) 拮抗剂。
  • HY-16079
    AZD3514 Inhibitor 98.77%
    AZD3514是口服的雄激素受体负调节剂,Ki为2.2 μM,可降低AR蛋白的表达。
  • HY-70002A
    N-desmethyl Enzalutamide 99.14%
    N-desmethyl Enzalutamide(N-desmethyl MDV3100)是Enzalutamide(MDV3100)的主要代谢物。
  • HY-11027
    MK-0773 Inhibitor 99.48%
    MK-0773 是一种选择性雄激素受体调节剂 (selective androgen receptor modulators),与 AR 结合,IC50 值为 6.6 nM。
  • HY-109619
    D4-abiraterone Antagonist 99.42%
    D4-abiraterone 是阿比特龙的主要代谢产物。D4-abiraterone 是 CYP17A1, 3β-羟基类固醇脱氢酶 (3 βHSD) 和类固醇-5α-还原酶 ( SRD5A ) 的抑制剂,也是雄激素受体的拮抗剂。
  • HY-13981
    LGD-4033 Modulator 98.68%
    LGD-4033是一种新型的非类固醇, 口服SARM, 以高亲和力 (Ki为1 nM) 和选择性与雄激素受体结合。
  • HY-14383
    RAD140 Inhibitor 99.53%
    RAD140是有效的,口服生物有效的非甾体选择性雄激素受体调节剂 (SARM)。
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