1. GPCR/G Protein
  2. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor 相关产品 (43):

Cat. No. Product Name Effect Purity
  • HY-N0583
    Hydrocortisone Agonist 99.66%
    Hydrocortisone 是一种由肾上腺皮质分泌的固醇类激素或糖皮质激素。
  • HY-14648
    Dexamethasone Agonist 98.70%
    Dexamethasone 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。
  • HY-13683
    Mifepristone Antagonist 98.17%
    Mifepristone 是一种孕激素受体 (progesterone receptorPR) 拮抗剂,T47D 细胞检测中,IC50 为 0.2 nM,Mifepristone也是一种糖皮质激素受体(glucocorticoid receptorGR)拮抗剂,在 A549 细胞检测中,IC50 为 2.6 nM。
  • HY-B0214
    Prednisone Agonist 99.13%
    Prednisone (Adasone)是皮质类固醇试剂,有免疫抑制作用。
  • HY-17463
    Prednisolone Agonist >98.0%
  • HY-15710
    Cort108297 Antagonist
    Cort108297 是一种高亲和性的特异性糖皮质激素受体 (GR) 拮抗剂,Ki 值为 0.45 nM。
  • HY-B1829A
    Dexamethasone phosphate disodium Agonist
    Dexamethasone phosphate disodium is a glucocorticoid receptor agonist.
  • HY-B1900
    Methylprednisolone succinate Agonist 99.14%
    Methylprednisolone succinate 是一种合成的糖皮质激素,被广泛用作抗炎剂。
  • HY-13580
    Budesonide Agonist >98.0%
  • HY-B0154
    Fluticasone propionate Agonist 99.77%
  • HY-14648A
    Dexamethasone acetate Agonist 99.34%
  • HY-N0835
    (20S)-Protopanaxatriol Agonist >98.0%
    (20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptoroestrogen receptor 起作用,同时为 LXRα 的抑制剂, PPARγ 的激活剂。
  • HY-B0636
    Triamcinolone acetonide Agonist 99.08%
    Triamcinolone Acetonide的有效性是prednisone的八倍。
  • HY-B0328
    Triamcinolone Inhibitor 99.15%
  • HY-13600
    Clobetasol propionate Agonist >98.0%
    Clobetasol propionate为抗炎皮质类固醇,可作用于各种皮肤病。
  • HY-17461
    Cortisone Agonist 98.08%
  • HY-77839
    Cortodoxone Agonist 99.35%
    Cortodoxone是一种糖皮质类固醇激素,可氧化为皮质醇 (Hydrocortisone) 。
  • HY-13570
    Betamethasone Agonist 99.24%
  • HY-B1121
    Flunisolide Activator 99.61%
    Flunisolide是一种皮质类固醇, 常用于治疗过敏性鼻炎。Flunisolide的主要作用机制是激活糖皮质激素受体, 意味着它具有抗炎作用。
  • HY-B1183
    Hydrocortisone acetate Agonist 99.07%
    Hydrocortisone醋酸盐是一种皮质类固醇, 用来减少轻微皮肤刺激或痔疮引起的肿胀, 搔痒和疼痛。