1. GPCR/G Protein
  2. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor 相关产品 (50):

Cat. No. Product Name Effect Purity
  • HY-14648
    Dexamethasone Agonist 99.70%
    Dexamethasone 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。
  • HY-N0583
    Hydrocortisone Agonist 99.66%
    Hydrocortisone 是一种由肾上腺皮质分泌的固醇类激素或糖皮质激素。
  • HY-13683
    Mifepristone Antagonist 98.17%
    Mifepristone 是一种孕激素受体 (progesterone receptorPR) 拮抗剂,T47D 细胞检测中,IC50 为 0.2 nM,Mifepristone也是一种糖皮质激素受体(glucocorticoid receptorGR)拮抗剂,在 A549 细胞检测中,IC50 为 2.6 nM。
  • HY-17463
    Prednisolone Agonist >98.0%
  • HY-13580
    Budesonide Agonist >98.0%
  • HY-111490
    Desisobutyryl-ciclesonide 99.53%
    Desisobutyryl-ciclesonide 是 Ciclesonide 的活性代谢产物。Desisobutyryl-ciclesonide 对糖皮质激素受体 (glucocorticoid receptor) 具有亲和力。
  • HY-14864
    Mapracorat Agonist
    Mapracorat 是新型的非甾类有选择性的 glucocorticoid receptor 激动剂。
  • HY-111453
    AZD7594 Modulator 98.70%
    AZD7594 是一种有效的,选择性非甾体类糖皮质激素受体 (glucocorticoid receptor) 调节剂,IC50 值为 0.9 nM。
  • HY-B0214
    Prednisone Agonist 99.35%
    Prednisone (Adasone)是皮质类固醇试剂,有免疫抑制作用。
  • HY-N0835
    (20S)-Protopanaxatriol Agonist >98.0%
    (20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptoroestrogen receptor 起作用,同时为 LXRα 的抑制剂, PPARγ 的激活剂。
  • HY-B0154
    Fluticasone propionate Agonist 99.57%
  • HY-14648A
    Dexamethasone acetate Agonist 99.34%
  • HY-B0328
    Triamcinolone Inhibitor 99.15%
  • HY-B0260
    Methylprednisolone Agonist 99.67%
  • HY-B1829A
    Dexamethasone phosphate disodium Agonist 99.68%
    Dexamethasone phosphate disodium is a glucocorticoid receptor agonist.
  • HY-B0636
    Triamcinolone acetonide Agonist 99.08%
    Triamcinolone Acetonide的有效性是prednisone的八倍。
  • HY-77839
    Cortodoxone Agonist 98.74%
    Cortodoxone是一种糖皮质类固醇激素,可氧化为皮质醇 (Hydrocortisone) 。
  • HY-13570
    Betamethasone Agonist 99.24%
  • HY-15709
    AL 082D06 Antagonist 98.65%
    AL 082D06 是一种选择性的非甾体类糖皮质激素受体 (GR) 拮抗剂,Ki 为 210 nM。
  • HY-14234
    Glucocorticoid receptor agonist Agonist 98.57%
    Glucocorticoid receptor agonist是Glucocorticoid受体激动剂。
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