1. Cell Cycle/DNA Damage
  2. Haspin Kinase

Haspin Kinase

Haspin is a protein kinase that regulates chromosome and spindle function during mitosis and meiosis. Haspin expression is detected in fetal liver, skin, kidney, small intestine and in all proliferating cells. Haspin phosphorylates H3 thr3 (H3T3ph) in human cell lines and depletion of Haspin by RNA interference reveals that Haspin is required for H3 thr3 phosphorylation in mitotic cells. Phosphorylation of H3T3ph by Haspin is necessary for chromosomal passenger complex (CPC) accumulation at centromeres. H3T3ph then positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis.

Haspin Kinase 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-15217
    CHR-6494 Inhibitor 98.12%
    CHR-6494是Haspin(单倍体生殖细胞特异性核蛋白激酶)抑制剂,能阻断H3T3ph的磷酸化。