1. Neuronal Signaling
  2. Monoamine Oxidase

Monoamine Oxidase

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase 相关产品 (35):

Cat. No. Product Name Effect Purity
  • HY-B1496
    Tranylcypromine hemisulfate Inhibitor 99.82%
    Tranylcypromine hemisulfate 是 LSD1 抑制剂,同时也是 MAO 的不可逆、非选择性抑制剂,常用于治疗抑郁症。
  • HY-14197A
    Clorgiline hydrochloride Inhibitor 99.53%
  • HY-14199
    R-(-)-Deprenyl hydrochloride Inhibitor 99.86%
  • HY-B1018A
    Phenelzine sulfate Inhibitor 98.70%
    Phenelzine硫酸盐是一种非选择性和不可逆的单胺氧化酶抑制剂 (MAOI), 用作抗抑郁药和抗焦虑药。
  • HY-N0529
    Rosmarinic acid Inhibitor 99.06%
    迷迭香酸 (Rosmarinic acid) 是一种天然多酚物质,具有抗氧化、抗炎活性。
  • HY-100546A
    GSK-LSD1 Dihydrochloride Inhibitor >98.0%
    GSK-LSD1 Dihydrochloride是有效,选择性,不可逆的赖氨酸特异性脱甲基酶 (LSD1) 抑制剂,IC50 值为16 nM。
  • HY-100179
    CR4056 Inhibitor 98.32%
    CR4056 是一个选择性的人重组 MAO-A 抑制剂,其 IC50 值为 202.7 nM。 CR4056 也是咪唑啉-2 受体 (I2R) 的配体,其 IC50 值为 596 nM。
  • HY-70057
    Safinamide Inhibitor 99.77%
    Safinamide (EMD 1195686; FCE 26743)是可逆的MAO-B抑制剂,IC50为98 nM,比对MAO-A的抑制性高5918倍。
  • HY-14605
    Rasagiline mesylate Inhibitor
  • HY-A0091
    Pargyline hydrochloride Inhibitor 99.45%
  • HY-16677A
    Mofegiline hydrochloride Inhibitor
    Mofegiline(MDL72974A)盐酸盐是酶活化的不可逆MAO-B抑制剂,对MAO-A和MAO-B的IC50分别为680和3.6 nM。
  • HY-B0886
    Iproniazid phosphate Inhibitor 99.47%
    Iproniazid是一种非选择性的,不可逆的单胺氧化酶抑制剂 (MAOI)。
  • HY-100027A
    Ro 41-1049 hydrochloride Inhibitor 99.79%
    Ro 41-1049盐酸盐是一种选择性的单胺氧化酶A型(MAO-A)抑制剂。
  • HY-B0884
    Minaprine Inhibitor 99.82%
  • HY-B0534
    Moclobemide Inhibitor
    Moclobemide(Ro111163)是可逆的单胺氧化酶(MAO)抑制剂,IC50为6.1 μM,可作用于重度抑郁症。
  • HY-N0159
    Paeonol Inhibitor 99.98%
    Paeonol 是牡丹根的活性提取物,Paeonol 抑制 MAO-AMAO-BIC50 分别为 54.6 μM 和 42.5 μM。
  • HY-B1083
    Modaline sulfate Inhibitor 99.40%
    Modaline硫酸盐是MAO抑制剂, 用于治疗抑郁症。
  • HY-B1199
    Nialamide Inhibitor
    Nialamide是一种非选择性的, 不可逆的单胺氧化酶抑制剂 (MAOI), 用作抗抑郁药。
  • HY-14200
    TVP1022 Inhibitor 99.60%
  • HY-14201
    Lazabemide Inhibitor 99.71%
    Lazabemide(Ro 19-6327/000)是MAO-B选择性可逆性抑制剂,IC50值为30nM,对MAO-A无活性(IC50>100uM)。