1. Immunology/Inflammation
  2. Salt-inducible Kinase (SIK)

Salt-inducible Kinase (SIK)

Salt-inducible Kinases (SIK) are a family of related serine-threonine kinases. In cultured adrenocortical cells, SIK1 is rapidly but transiently induced by adrenocorticotropin (ACTH) treatment, suggesting that it contributes to ACTH-mediated induction of steroidogenic enzymes. SIK2 is found in adipocytes and phosphorylates a specific serine residue in insulin receptor substrate-1. Members of the SIK family are emerging as important modulators of key processes such as steroid hormone biosynthesis by the adrenal cortex and insulin signaling in adipocytes.

Salt-inducible Kinase (SIK) 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-15776
    HG-9-91-01 Inhibitor
    HG-9-91-01 是一种有效的选择性盐诱导型激酶 (SIK) 抑制剂,作用于 SIK1SIK2SIK3IC50 分别为 0.92 nM,6.6 nM 和 9.6 nM。
  • HY-101147
    YKL-05-099 Inhibitor 99.38%
    YKL-05-099是一种盐诱导型激酶 (SIK) 探针; 抑制SIK2的IC50值为40 nM。