1. GPCR/G Protein
  2. Somatostatin Receptor

Somatostatin Receptor

Somatostatin receptor is a family of G protein-coupled seven transmembrane receptors. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. Include SSTR1, SSTR2, SSTR3, SSTR4, SSTR5. SSTR1 is expressed in highest levels in jejunum and stomach. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. SSTR3 is functionally coupled to adenylyl cyclase. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.

Somatostatin Receptor 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-17365
    Octreotide acetate Agonist 99.78%
    Octreotide acetate是长效的天然生长抑素合成类似物,是比生长抑素更有效的生长激素胰高血糖素胰岛素的抑制剂。
  • HY-79135
    Pasireotide ditrifluoroacetate
    Pasireotide ditrifluoroacetate 是一种稳定的环六肽生长激素抑制素模拟物,与人 somatostatin receptor 具有很高的亲和性,包括 sst1/2/3/4/5,pKi 值分别为 8.2/9.0/9.1/<7.0/9.9。
  • HY-P0036
    Octreotide Agonist 99.15%
    Octreotide 是一种生长抑素类似物,能够与 somatostatin 受体结合,主要有 2,3,5 亚型,可增强 Gi 活性,降低胞内 cAMP 的产生。
  • HY-13466
    MK-4256 Antagonist 98.63%
    MK-4256 是一种有效的选择性 SSTR3 拮抗剂。在人和小鼠受体结合测定中,IC50 分别为 0.66 nM 和 0.36 nM。
  • HY-79136
    Pasireotide L-aspartate salt 99.44%
    Pasireotide(SOM 230)是一环六肽类somatostatin模拟类似物,对人somatostatin受体有很高的亲和力,对SST1、2、3、4和5的pKi值分别为8.2、9.0、9.1、<7.0和9.9。
  • HY-P1672
    PEN-221 Inhibitor
    PEN-221是靶向生长抑素受体2 (SSTR2)的细胞毒性缀合物,IC50 为10 nM。
  • HY-102037
    SSTR5 antagonists 1 Antagonist
    SSTR5 antagonists 1是一种有效,选择性,可口服的生长抑素受体亚型5 (SSTR5) 拮抗剂,对hSSTR5和mSSTR5的 IC50 分别为9.6和 57 nM。 (化合物25a)
  • HY-P0061A
    Vapreotide acetate 99.61%
    Vapreotide acetate是生长抑素的合成类似物,用于治疗静脉曲张出血; 也具有抗肿瘤活性。
  • HY-16381
    Pasireotide
    Pasireotide(SOM 230)是稳定的环己肽生长激素抑制素(somatostatin)类似物,能与人生长激素抑制素(somatostatin)受体特异且高亲和性地结合,对sst1/2/3/4/5的pKi分别为8.2/9.0/9.1/<7.0/9.9。
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