1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. Tyk2-IN-5

Tyk2-IN-5 

目录号: HY-111745
产品使用指南

Tyk2-IN-5 (compound 6) 是一个强效的、选择性的、具有口服活性的酪氨酸激酶 2 (Tyk2) 的抑制剂,作用于 JH2 结构域,其对 Tyk2 JH2 的 Ki 值为 0.086 nM,对 IFNα 的 IC50 值为 25 nM。能够高效抑制药效学老鼠模型中的 IFNγ 的产生,对老鼠关节炎模型具有完全的疗效。

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Tyk2-IN-5 Chemical Structure

Tyk2-IN-5 Chemical Structure

CAS No. : 1797432-62-2

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Description

Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1].

IC50 & Target[1]

Tyk2 JH2

0.086 nM (Ki)

IFNα

25 nM (IC50)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

434.43

Formula

C₂₁H₁₉FN₈O₂

CAS No.

1797432-62-2

SMILES

O=C1C(NC2=NN3C(C(NC)=C2)=NC=C3C(N[C@H]4[C@@H](F)C4)=O)=CC=CN1C5=CC=CC=N5

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
Tyk2-IN-5
目录号:
HY-111745
需求量:

Tyk2-IN-5

Cat. No.: HY-111745