2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. UbcH5c-IN-1

UbcH5c-IN-1 (compound 6d) 是一种有效的、选择性的小分子泛素结合酶 UbcH5c 抑制剂，其与 E2 UbcH5c-IN-1 活性位点Cys85共价结合的 Kd 值为 283 nM，是开发新型类风湿性关节炎活性分子的先导化合物。

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UbcH5c-IN-1 Chemical Structure

UbcH5c-IN-1 Chemical Structure

CAS No. : 2123480-72-6

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UbcH5c-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent[1].

IC50 & Target

Kd: 283 nM (E2 UbcH5c)[1].
体内研究
(In Vivo)

UbcH5c-IN-1 (compound 6d) (5 and 20 mg/kg, p.o., daily, 10-20 days) treatment in Freund’s adjuvant (CFA)-induced adjuvant arthritis (AA) rat model results in appreciable decreases in the arthritis index score and hind paw swelling rate compared with those of the vehicle-treated AA model control group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Freund’s adjuvant (CFA)-induced adjuvant arthritis (AA) rat model[1].
Dosage: 5 and 20 mg/kg
Administration: Oral administration daily between day 10-20 postimmunization.
Result: Resulted in appreciable decreases in the arthritis index score and hind paw swelling rate compared with those of the vehicle-treated AA model control group.
分子量

413.30

Formula

C22H21BrO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UbcH5c-IN-1 相关分类

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Keywords:

UbcH5c-IN-12123480-72-6E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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