2. Cytoskeleton
  3. Integrin
  4. Abituzumab

Abituzumab  (Synonyms: EMD 525797; DI17E6)

目录号: HY-P99183 纯度: 99.38%
COA

摩尔计算器

Abituzumab (DI17E6) 是一种人源化抗 integrin αV 单克隆抗体 (IgG2 型)。Abituzumab 能有效减少 FAK、 Akt 和 ERK 的磷酸化。Abituzumab 可用于癌症，尤其是前列腺癌的研究。

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Abituzumab Chemical Structure

Abituzumab Chemical Structure

CAS No. : 1105038-73-0

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Abituzumab 相关抗体

Top Publications Citing Use of Products

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer[1].

IC50 & Target

Integrin αV[1].
体外研究
(In Vitro)

Abituzumab (DI17E6) (0.01, 0.1, 1, 10, 30,100 µg/mL; 24 h) inhibits adhesion of PCa cells to multiple extracellular matrix proteins but not collagen I[1]
Abituzumab (100 µg/mL; 12, 18 h) inhibits inhibits motility and invasion of PCa cells[1].
Abituzumab (0.01, 0.1, 1, 10, 30,100 µg/mL; 24 h) inhibits the ability of PCa cells to adhere to osteoblast and bone stromal cell lines[1].
Abituzumab (100 µg/mL; 24 h) blocks integrin-mediated cell signaling in PCa cancer cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Abituzumab 相关抗体:

Cell Viability Assay[1]

Cell Line: PCa cells
Concentration: 0.01, 0.1, 1, 10, 30,100 µg/mL
Incubation Time: 24 h
Result: Promoted detachment of PCa cells from vitronectin (up to approximately 20% cells detached at 100 μg/mL), osteopontin (up to approximately 10% cells detached at 100 μg/mL) and fibronectin (up to approximately 10% cells detached at 100 μg/mL) but not from collagen I.

Cell Invasion Assay[1]

Cell Line: PCa cells
Concentration: 100 µg/mL
Incubation Time: 12, 18 h
Result: Inhibited invasive ability by approximately 25 to 30% compared to vehicle, and inhibited motility by approximately 30 to 40%.

Cell Viability Assay[1]

Cell Line: PCa, hFOB, Saos2, HS-5, HDMEC cells
Concentration: 0.01, 0.1, 1, 10, 30,100 µg/mL
Incubation Time: 24 h
Result: Inhibited PCa cells adhesion to human osteoblast cell lines hFOB and Saos2 and a bone marrow stromal cell line, HS-5.
Promoted detachment of PCa cells from to a known expressor of αv integrins, HDMEC cells.

Western Blot Analysis[1]

Cell Line: PC3, DU145, C4-2B, LNCaP, ARCaP and VCaP cells
Concentration: 100 µg/mL
Incubation Time: 24 h
Result: Inhibited FAK phosphorylation starting at 12 h and 6 h in C4-2B and LNCaP, respectively; AKT phosphorylation starting at 3 h and 2 h in C4-2B and LNCaP, respectively; and ERK phosphorylation at starting at 1 h and 1.5 h in C4-2B and LNCaP, respectively.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Abituzumab 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abituzumab1105038-73-0EMD 525797 DI17E6EMD525797EMD-525797IntegrinPC3DU145C4-2BLNCaPARCaP,VCaPprostate cancerInhibitorinhibitorinhibit

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