2. Immunology/Inflammation Apoptosis
  3. Interleukin Related Caspase Apoptosis
  4. Ac-YVAD-CHO acetate

Ac-YVAD-CHO acetate  (Synonyms: L-709049 acetate)

目录号: HY-120019A
产品使用指南

摩尔计算器

Ac-YVAD-CHO (L-709049) acetate 是一种有效的、可逆的、特异性的四肽白介素 1β 转化酶 (ICE) 抑制剂，小鼠和人类 Ki 值分别为 3.0 和 0.76 nM。Ac-YVAD-CHO acetate 也是一种 caspase-1 抑制剂。Ac-YVAD-CHO acetate 可抑制成熟 IL-lβ 的产生。

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Ac-YVAD-CHO acetate Chemical Structure

Ac-YVAD-CHO acetate Chemical Structure

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Ac-YVAD-CHO acetate 的其他形式现货产品:

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Other Forms of Ac-YVAD-CHO acetate:

Ac-YVAD-CHO acetate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a caspase-1 inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ[1][2][3].

IC50 & Targethttps://pubmed.ncbi.nlm.nih.gov/10903723[1][3]

Caspase-1

 

IL-1β

 

体外研究
(In Vitro)

Ac-YVAD-CHO acetate 抑制小鼠和人 IL-1β 的 IC50 值分别为 2.5 和 0.7 μM[1]。
Ac-YVAD-CHO (0.01-100 μM) acetate 可降低经 LPS 处理的血浆和腹膜液中 IL-1β 的升高[1]。
Ac-YVAD-CHO (15.6 μM) acetate 减少 NO 诱导的胸腺细胞凋亡[3]。
Ac-YVAD-CHO (15.6 μM，12 小时) acetate 抑制 SNAP 处理的胸腺细胞中 NO 诱导的 PARP 裂解[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-YVAD-CHO acetate 相关抗体:

Western Blot Analysis[3]

Cell Line: SNAP-treated thymocytes
Concentration: 15.6 μM
Incubation Time: 12 h
Result: Reduced PARP cleavage.
体内研究
(In Vivo)

Ac-YVAD-CHO (30 mg/kg; i.p.; 6 小时) acetate 抑制 P. acnes 致敏小鼠血液中的 IL-1β 水平[1]。
Ac-YVAD-CHO (2-8 μg，intrastriatal infusion) acetate 减弱大鼠纹状体中喹啉酸 (QA) 诱导的细胞凋亡[2]。
Ac-YVAD-CHO (10 和 50 mg/kg; i.p.; 1 小时) acetate 迅速从血液中清除，并在注射后 30 和 60 分钟急剧下降至大约 1 和 0.2 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. acnes-sensitized mice[1]
Dosage: 50 mg/kg
Administration: I.p.
Result: Suppressed IL-1β levels in blood.
Animal Model: Quinolinic acid-treated Rats[2]
Dosage: 2-8 μg
Administration: Intrastriatal infusion.
Result: Attenuated Quinolinic acid (QA)-induced increases in p53 and apoptosis in rat striatum.
Inhibited QA-induced increases in caspase-1 activity and p53 protein levels, with no effect on QA-induced IκB-α degradation, NF-κB or AP-1 activation.
分子量

552.57

Formula

C25H36N4O10
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ac-YVAD-CHO acetate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-YVAD-CHOL-709049L709049L 709049Interleukin RelatedCaspaseApoptosisILTetrapeptideInterleukin-lβconvertingenzymethymocyteQuinolinic acidInhibitorinhibitorinhibit

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