2. Neuronal Signaling
  3. Cholinesterase (ChE) Beta-secretase Amyloid-β
  4. AChE/BChE-IN-12

AChE/BChE-IN-12 (compound 10b)，一种 3,5-二甲氧基类似物，是一种有效的 AChE、BChE 和 β-secretase-1 (BACE-1) 抑制剂，IC50 值分别为 2.57、3.26 和 10.65 μM。 AChE/BChE-IN-12 通过被动扩散穿过血脑屏障并抑制淀粉样蛋白-β 单体的自聚集。 AChE/BChE-IN-12 可用于阿尔茨海默病 (AD) 研究。

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AChE/BChE-IN-12 Chemical Structure

AChE/BChE-IN-12 Chemical Structure

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AChE/BChE-IN-12 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Beta-secretase 亚型特异性产品:

查看所有亚型
BACE1 BACE2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC50 values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-β monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target

EeAChE

2.57 ± 0.3 μM (IC50)

eqBCHE

3.26 ± 0.1 μM (IC50)

BACE1

10.65 ± 0. μM (IC50)

体外研究
(In Vitro)

AChE/BChE-IN-12 (compound 10b) 与 AChE 的外周阴离子位点 (PAS) 和催化阴离子位点 (CAS) 残基相互作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BChE-IN-12 相关抗体:
分子量

435.43

Formula

C23H21N3O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/BChE-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-12Cholinesterase (ChE)Beta-secretaseAmyloid-βBACEβ-Secretase β-amyloid peptideAβAbetaAlzheimer’s disease (AD)blood-brain barrieramyloid-βInhibitorinhibitorinhibit

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