2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. AChE-IN-62

AChE-IN-62 (Compound 1) 是一种有效的混合型选择性乙酰胆碱酯酶 (AChE) 抑制剂，IC50 值为 0.421 μM。AChE-IN-62 具有良好的血脑屏障透过性和神经保护作用。AChE-IN-62 能抑制 Aβ1?42 的聚集，IC50 值为 44.64 μM。AChE-IN-62 也是一种有效的多靶点定向配体 (MTDL)，可以用于阿尔兹海默症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AChE-IN-62 Chemical Structure

AChE-IN-62 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AChE-IN-62 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ1?42 with an IC50 value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease[1].

IC50 & Target

IC50: 0.421 μM (AChE)[1].
体外研究
(In Vitro)

AChE-IN-62 (50 μM; 24-48 h) 能有效抑制 Aβ1−42 的聚集，IC50 值为 44.64 μM[1]。
AChE-IN-62 (5-20 μM; 24 h) 在 SH-SY5Y 和 Neuro2A 细胞中，能够改善 H2O2 (200 μM; 24 h) 和Okadaic acid (HY-N6785) (30 nM; 24 h) 介导的细胞神经毒性，具有神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-62 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y, Neuro2A
Concentration: 5 μM, 10 μM, 20 μM;
Incubation Time: 24 h
Result: Inhibited the cell death mediated by H2O2 (200 μM; 24 h) and Okadaic acid (HY-N6785).
体内研究
(In Vivo)

AChE-IN-62 (Compound 1) ( 10-20 mg/kg; 腹腔注射; 一天一次连续 7 天) 在瑞士白化痴呆小鼠中通过修复大脑皮层和海马组织的损伤来改善东莨菪碱 (HY-N0296) (3 mg/kg; 腹腔注射; 一天一次连续 7 天) 诱导的记忆力下降和学习障碍，对东莨菪碱造成的伤害起到了保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dementia model of Swiss albino mice mediated by scopolamine[1].
Dosage: 5 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection (i.p.); Once daily for 7 days. Before scopolamine (HY-N0296) treatment (3 mg/kg; i.p.; Once daily for 7 days)
Result: Reduced the recognition ratio (T2/T1) in mice (a lower T2/T1 value indicates stronger short-term recognition memory).
Significantly enhanced the step-through latency (STL) (a decrease in STL indicates impaired memory).
分子量

431.53

Formula

C19H21N5O3S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-62 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-62Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’s disease (AD)multi-target- directed ligand (MTDL)SH-SY5Ymulti-target- directed ligand (MTDL)Neuro2ABlood-Brain Barrier (BBB)neuroprotectionInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AChE-IN-62
目录号：
HY-161466
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z