2. Neuronal Signaling
  3. Cholinesterase (ChE) Monoamine Oxidase
  4. AChE/MAO-IN-2

Dual AChE-MAO B-IN-5 是一种茚满酮衍生物，是一种有效的双重 AChE/MAO-B 抑制剂，对 AChE、MAO-B 和 MAO-A 的 IC50 值分别为 0.0224、0.0412 和 0.1116 μM。Dual AChE-MAO B-IN-5 具有抗氧化活性，防止 β-淀粉样斑块聚集。Dual AChE-MAO B-IN-5 可用于阿尔茨海默病 (AD) 研究。

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AChE/MAO-IN-2 Chemical Structure

AChE/MAO-IN-2 Chemical Structure

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AChE/MAO-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dual AChE-MAO B-IN-5, indanone derivative, is a potent dual AChE/MAO-B inhibitior with IC50 values of 0.0224, 0.0412, and 0.1116 μM for AChE, MAO-B and MAO-A, respectively. Dual AChE-MAO B-IN-5 has antioxidant activity and prevents β-amyloid plaque aggregation. Dual AChE-MAO B-IN-5 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target[1]

AChE

0.0224 μM (IC50)

MAO-B

0.0412 μM (IC50)

MAO-A

0.1116 μM (IC50)

体外研究
(In Vitro)

Dual AChE-MAO B-IN-5 (conpound D29; 0.1-1 μM) 具有抗氧化活性，其 IC50 值为 0.188 μM[1]。
Dual AChE-MAO B-IN-5 (0.1-1 μM) 增加胆碱能活性并防止 β-淀粉样斑块的形成，0.1 μM 和 1 μM 的抑制率分别为 82.748% 和 71.891%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/MAO-IN-2 相关抗体:
分子量

378.46

Formula

C23H26N2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/MAO-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/MAO-IN-2Cholinesterase (ChE)Monoamine OxidaseMAOIndanoneantioxidantβ-amyloidAlzheimer’s diseaseplaqueInhibitorinhibitorinhibit

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