2. Apoptosis Immunology/Inflammation
  3. Apoptosis Aryl Hydrocarbon Receptor
  4. AHR agonist 3

AHR agonist 3 是一种芳香烃受体 (AhR) 激动剂，可通过激活肿瘤抑制转录程序诱导细胞周期停滞或细胞凋亡 (apoptosis)。AHR agonist 3 通过 AhR 抑制三阴性乳腺癌 (TNBC) 干细胞生长，同时对正常人原代细胞毒性极小，可用于癌症研究。

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AHR agonist 3 Chemical Structure

AHR agonist 3 Chemical Structure

CAS No. : 23749-58-8

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AHR agonist 3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].

体外研究
(In Vitro)

AHR agonist 3 (Analog 523) (10 nΜ; 24 hour or 2-3 weeks) 可诱导 AhR WT 和 AhR KO 的 MDA-MB-468 细胞周期停滞并抑制克隆生成[1]。
AHR agonist 3 (0-10 μΜ; 72 小时) 可使乳腺癌细胞，而非正常乳腺上皮细胞或非致瘤细胞发生 AhR 依赖性凋亡和生长抑制，并通过 AhR 抑制 TNBC 干细胞生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AHR agonist 3 相关抗体:

Cell Proliferation Assay[1]

Cell Line: AhR WT and AhR KO MDA-MB-468 cells
Concentration: 10 nM
Incubation Time: 24 hours or 2−3 weeks
Result: Induced an AhR-dependent S+G2/M phase arrest for Short-term (24 h) treatment.
Completely exhibited the clonogenicity of AhR expressing cells while exhibiting a minimal impact on AhR deficient cells.

Apoptosis Analysis[1]

Cell Line: MDA-MB-468 cells, MCF10A, HEK293T and normal primary human fibroblast
Concentration: 0-10 μΜ
Incubation Time: 48-72 hours
Result: Human mammary epithelial cells (HMECs), nonmalignant mammary epithelial line Induced AhR-dependent apoptosis and growth inhibition in cancerous but not normal cells.
Inhibited TNBC stem cell growth via AhR.
分子量

270.28

Formula

C18H10N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AHR agonist 3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AHR agonist 323749-58-8AHR agonist3AHR agonist-3ApoptosisAryl Hydrocarbon ReceptorAhRTNBCMDA-MB-468MCF10AHEK293THMECsST2 cellsInhibitorinhibitorinhibit

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