2. Protein Tyrosine Kinase/RTK Epigenetics Cell Cycle/DNA Damage
  3. Anaplastic lymphoma kinase (ALK) HDAC
  4. ALK/HDAC-IN-1

ALK/HDAC-IN-1 是 ALK 和 HADC6 的双重抑制剂，IC50 分别为 16 nM 和 1.03 μM。ALK/HDAC-IN-1 具有抗肿瘤活性。

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ALK/HDAC-IN-1 Chemical Structure

ALK/HDAC-IN-1 Chemical Structure

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ALK/HDAC-IN-1 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALK/HDAC-IN-1 is a dual inhibitor for ALK and HADC6, with IC50s of 16 nM and 1.03 μM, respectively. ALK/HDAC-IN-1 exhibits antitumor activity[1].

IC50 & Target

HDAC6

1.03 μM (IC50)

HDAC8

1.69 μM (IC50)

HDAC1

10.8 μM (IC50)

HDAC11

16.6 μM (IC50)

体外研究
(In Vitro)

ALK/HDAC-IN-1 抑制癌细胞 A549，HepG2，MCF7，U87MG 和 H2228 增殖，IC50 分别为 0.33，0.59，0.55，0.62 和 0.44 μM[1]。
ALK/HDAC-IN-1 抑制 CYP450 酶 CYP2C9，IC50 为 2.65 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALK/HDAC-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A549, HepG2, MCF7, U87MG and H2228
Concentration:
Incubation Time: 48 h
Result: Inhibited proliferations with sub-micromolar level IC50 values.

Western Blot Analysis[1]

Cell Line: H2228
Concentration: 2 μM
Incubation Time: 6 h
Result: Ptomoted acetylation of α-tubulin and histone H3.
体内研究
(In Vivo)

ALK/HDAC-IN-1 (0-20 mg/kg，腹腔注射 21 天) 抑制 A549 异种移植 BALB/c 小鼠的肿瘤生长，无明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 xenografted BALB/c mice[1]
Dosage: 0-20 mg/kg
Administration: i.p., once daily for 21 days
Result: Decrease tumor growth with TGIs of 68% and 85%, with dose of 10 and 20 mg/kg, respectively.
分子量

489.57

Formula

C27H31N5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALK/HDAC-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK/HDAC-IN-1Anaplastic lymphoma kinase (ALK)HDACAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Histone deacetylasesA549HepG2MCF7U87MGH2228ALKCYP450CYP2C9BALB/cInhibitorinhibitorinhibit

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产品名称：
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目录号：
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