2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Andolast

Andolast  (Synonyms: CR 2039; Dizolast)

目录号: HY-106358A
产品使用指南

摩尔计算器

Andolast (CR 2039) 是一种抗过敏剂。Andolast 可抑制 cAMP-磷酸二酯酶，IC50 值为 50 μM。Andolast 可用于哮喘的研究。

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Andolast Chemical Structure

Andolast Chemical Structure

CAS No. : 143330-46-5

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Andolast 的其他形式现货产品:

Customer Review

Other Forms of Andolast:

Andolast 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma[1].

体内研究
(In Vivo)

Andolast (CR 2039) (i.v. or i.m.) inhibits rat passive cutaneous anaphylaxis (PCA) with an ED50 of 0.1 mg/kg[1].
CR 2039 (10-100 mg/kg; i.v. or i.m.) inhibits the microvascular permeability changes in a model of allergic conjunctivitis in sensitized guinea-pigs[1].
CR 2039 (0-1000 μM; i.v.) inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 value of 50 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Hartley guinea-pigs (300-500 g) [1]
Dosage: 10-100 mg/kg
Administration: I.M; I.V.
Result: Showed dose-related significant protection against lgE-dependent bronchial anaphylaxis induced by aerosolized antigen in anesthetized guinea-pigs.
Delayed dose dependently the onset of bronchoconstriction induced by aerosolized antigen.
分子量

379.29

Formula

C15H11N9Na2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 11.36 mg/mL (29.95 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6365 mL 13.1825 mL 26.3650 mL
5 mM 0.5273 mL 2.6365 mL 5.2730 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Andolast 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6365 mL 13.1825 mL 26.3650 mL 65.9126 mL
5 mM 0.5273 mL 2.6365 mL 5.2730 mL 13.1825 mL
10 mM 0.2637 mL 1.3183 mL 2.6365 mL 6.5913 mL
15 mM 0.1758 mL 0.8788 mL 1.7577 mL 4.3942 mL
20 mM 0.1318 mL 0.6591 mL 1.3183 mL 3.2956 mL
25 mM 0.1055 mL 0.5273 mL 1.0546 mL 2.6365 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Andolast143330-46-5CR 2039 DizolastCR2039CR-2039Phosphodiesterase (PDE)anti-allergiccAMP-phosphodiesteraseasthmapassive cutaneous anaphylaxisInhibitorinhibitorinhibit

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