2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species Apoptosis
  4. Anti-inflammatory agent 47

Flo8 是一种强效的抗炎和抗氧化化合物。Flo8 能抑制细胞内活性氧 (ROS) 和一氧化氮 (NO) 的释放，并通过抑制炎症和凋亡信号通路来抑制神经元凋亡 apoptotic，可用于帕金森病 (PD) 的研究。

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Anti-inflammatory agent 47 Chemical Structure

Anti-inflammatory agent 47 Chemical Structure

CAS No. : 2925288-12-4

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Anti-inflammatory agent 47 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO) and suppresses neuronal apoptotic by inhibiting inflammatory and apoptotic signaling pathways. Flo8 can be used for Parkinson's Disease (PD) research[1].

体外研究
(In Vitro)

Compound Flo8 (5 μM, 10 μM, 18 小时) 对 BV2 细胞活力的抑制作用较小[1]。
Compound Flo8 (5 μM, 18小时) 对 BV2 细胞中 ROS 的产生具有明显的抑制作用[1]。
Compound Flo8 (5 μM, 10 μM, 18小时) 通过减少 BV2 细胞中炎症因子的表达，降低 SH-SY5Y 细胞的凋亡水平[1]。
Compound Flo8 (5 μM, 10 μM, 18小时) 抑制 LPS 诱导的小胶质细胞 M1 极化，促进 M2 极化[1]。
Compound Flo8 (5 μM, 10 μM, 18小时) 抑制 LPS 诱导的 BV2 细胞中 ERK，p38 和 JNK 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 47 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: BV2 cells
Concentration: 5 μM, 10 μM
Incubation Time: 18 h
Result: Exhibited low cytotoxicity at 5 μM concentration and showed minimal toxicity at 10 μM for BV2 cells.

Real Time qPCR[1]

Cell Line: BV2 cells
Concentration: 5 μM, 10 μM
Incubation Time: 18 h
Result: Suppressed LPS-induced expression of M1 markers and increased the mRNA level of CD206, Arg-1, and IL-10 in BV2 cells.
Decreased the mRNA expression levels of apoptosis-related genes BAX, Caspase3 and Cleaved Caspase3 but increased the expression levels of Bcl-2 in SH-SY5Y cells.

Western Blot Analysis[1]

Cell Line: BV2 cells
Concentration: 5 μM, 10 μM
Incubation Time: 18 h
Result: Inhibited phosphorylation of ERK, p38 and JNK in BV2 cells.
Inhibited LPS-induced expression of p-Iκ B-α, p-NF-κB in BV2 cells.
Decreased the protein expression levels of apoptosis-related genes BAX, Caspase3 and Cleaved Caspase3 but increased the expression levels of Bcl-2 in SH-SY5Y cells.

Immunofluorescence[1]

Cell Line: BV2 cells
Concentration: 5 μM, 10 μM
Incubation Time: 18 h
Result: Inhibited the translocation of NF-κB from the cytoplasm to the nucleus in BV2 cells.
体内研究
(In Vivo)

Compound Flo8 (15/35 mg/kg，腹腔注射，每天/两周) 能缓解 MPTP 诱导 C57BL/6J 小鼠大脑中的神经炎症并抑制神经凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MPTP C57BL/6J mice model[1]
Dosage: 15 mg/kg, 35 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Increased the mRNA expression of CD86, TNF-α, IL-6 and IL-1β but decreased CD206, Arg-1 and IL-10 in brain tissue.
Inhibited the expression of MPTP-induced phosphorylation of p38, ERK, JNK and NF-κ B.
Reduced dopamine levels in mouse serum in the MPTP group.
Increased the protein expression of Caspase3 and BAX but decreased the expression of Bcl2 after MPTP induction in brain tissue.
分子量

394.42

Formula

C25H18N2O3
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 47 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 472925288-12-4Reactive Oxygen SpeciesApoptosisParkinson’s disease. Inflammationanti-inflammatory agentreactive oxygen species (ROS)Inhibitorinhibitorinhibit

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