2. NF-κB
  3. NF-κB
  4. Anti-inflammatory agent 48

Anti-inflammatory agent 48 是一种抗炎剂，具有抑制 NF-κB 信号通路和激活 HO-1 表达的作用。

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Anti-inflammatory agent 48 Chemical Structure

Anti-inflammatory agent 48 Chemical Structure

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Anti-inflammatory agent 48 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-inflammatory agent 48 is an anti-inflammatory agent based on its role in inhibiting the NF-κB signaling pathway and activating HO-1 expression[1].

体外研究
(In Vitro)

Anti-inflammatory agent 48 (compound 1; 20 mg/kg) 在 LPS 诱导的 RAW 264.7 巨噬细胞中显示出 NO 抑制能力。与 Diclofenac 相比，Anti-inflammatory agent 48 通过激活 RAW 264.7 中的 Nrf2/HO-1 信号通路表现出优异的 NF-κB 抑制能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 48 相关抗体:
体内研究
(In Vivo)

Anti-inflammatory agent 48 (compound 1; 20 mg/kg) 通过上调 HO-1 和下调 NF-κB p65 磷酸化水平，显着改善葡聚糖硫酸钠 (DSS) 诱导的小鼠模型中的结肠炎[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

442.33

Formula

C24H21Cl2NO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 48 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 48NF-κBNuclear factor-κBNuclear factor-kappaBanti-inflammatory activityNrf2/HO-1NF-κB pathwayInhibitorinhibitorinhibit

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产品名称：
Anti-inflammatory agent 48
目录号：
HY-155646
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